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Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Targeting TGFβ can improve skin immunity in older people.

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.

Tea, especially green tea, shows promise in cosmetics for skin and hair benefits but more research is needed for effective use.

A surface with VEGF can specifically capture endothelial cells from flowing fluids.

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

A special stem cell fluid can speed up wound healing and hair growth in mice.

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

Increasing TSPO in the brain reduces anxiety and depression.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.

Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.

Nearly half of the studied men with long COVID had low testosterone, including younger men.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

KCNQ potassium channels help control the sensitivity of touch receptors in the skin.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.

TLR4 is important in aging-related diseases and could be a new treatment target.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Zinc pyrithione needs targeted delivery to the scalp for effective dandruff treatment.

Bariatric surgery helps with weight loss but can cause complications and nutritional deficiencies.

Marine algae compounds may improve skin health and promote hair growth.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

PCOS is a condition causing irregular periods, excess male hormones, and infertility, often managed by targeting insulin resistance and specific symptoms.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Omega-6 fats in certain cells boost male hormone production.

Different ligands change the shape of the TRPV3 ion channel in unique ways.