November 2022 in “Journal of the Endocrine Society” This case report highlights a rare ovarian steroid cell tumor as the cause of androgen excess in a 36-year-old woman and underscores the importance of thorough preoperative workup to avoid unnecessary surgery.
January 2022 in “International journal of Ayurveda and pharma research” This review discusses the Ayurvedic perspective on premature graying of hair (Akala Palitam) and reports no new clinical results, emphasizing the need for understanding its etio-pathogenesis for effective management.
November 2020 in “Elsevier eBooks” This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.
70 citations
,
February 2021 in “International Journal of Molecular Sciences” This review provides an overview of current research on AD-MSCs, PRP, and biomaterials, highlighting their safety and efficacy in treating soft tissue defects and chronic wounds without major side effects.
2 citations
,
March 2025 in “International Journal of Advanced Science and Engineering” This review highlights that nanoemulsions, especially those with droplet sizes under 200 nm, show promise in pharmaceuticals and cosmetics by improving drug stability, bioavailability, and reducing side effects, with potential applications in CNS diseases, cancer treatments, and skincare products.
December 2025 in “ADMET & DMPK” This review synthesizes recent research to propose a precision framework for treating androgenetic alopecia and alopecia areata based on genetic insights and pathway biology, highlighting the roles of androgen-receptor signaling, immune dysregulation, and emerging therapies like regenerative medicine and AI-assisted diagnostics.
In this study, researchers formulated and evaluated herbal hair serums incorporating natural ingredients like flax seed, fenugreek, and castor oil, finding that the best formulation supported hair growth with minimal side effects compared to existing herbal serums.
March 2014 in “Human Physiology” This study found that prolonged administration of DHEA improved long-term memory and brain activity balance in old rhesus macaques, with effects like increased motor activity and restored hair lasting a year.
117 citations
,
August 2019 in “Drug Design Development and Therapy” This review article provides an updated overview of the pharmacology, mechanism of action, clinical efficacy, and adverse events associated with topical minoxidil, a widely used treatment for androgenetic alopecia and other hair loss conditions, while noting that its exact mechanism is still not fully understood.
63 citations
,
March 2001 in “Fertility and Sterility” This study found that Diane 35 combined with finasteride led to a greater reduction in hirsutism scores over 12 months compared to Diane 35 alone.
50 citations
,
May 2000 in “Fertility and Sterility” This study found that flutamide was more effective than finasteride in reducing hair growth in women with hirsutism over a one-year period.
47 citations
,
March 2004 in “European journal of endocrinology” This study found that the combination of spironolactone and finasteride significantly improved hirsutism scores more than spironolactone alone in women, with similar side-effect profiles between treatments.
11 citations
,
January 2016 in “The Journal of Sexual Medicine” This study found that young women with nonclassic congenital adrenal hyperplasia had impaired sexual function and mild depressive symptoms compared to healthy women.
4 citations
,
January 2017 in “Acta Endocrinologica” This study found that both finasteride and metformin effectively reduced androgen levels and insulin resistance parameters in women with PCOS, without clear evidence of one treatment being superior.
1 citations
,
July 2019 in “The journal of applied laboratory medicine” This review analyzes 873 cases of female hyperandrogenism, primarily attributing it to polycystic ovarian syndrome, and explores sample testing for suspected neoplasms but reports no new clinical findings.
May 2023 in “The journal of sexual medicine” In this study, bilateral oophorectomy was reported as an effective treatment for normalizing androgen levels and resolving hypersexuality and related symptoms in a post-menopausal woman with ovarian hyperthecosis, suggesting its importance in addressing excess androgen production in such cases.
212 citations
,
May 2012 in “Genes & Development” This study identified a set of wound-induced genes in planarians that play a role in regeneration initiation, with some genes specifically activating within regenerative cells called neoblasts.
157 citations
,
December 2015 in “Journal of the American Academy of Dermatology” This case study reported significant but temporary hair regrowth and skin repigmentation in a patient with vitiligo and alopecia areata during treatment with oral ruxolitinib.
142 citations
,
December 1991 in “Antimicrobial Agents and Chemotherapy” This study reported that continuous intravenous dextran sulfate was toxic and ineffective as a treatment for symptomatic HIV infection, as it did not improve surrogate markers and caused significant side effects.
102 citations
,
August 2008 in “Genes & Development” This study found that laminin-511 is crucial for hair morphogenesis in mice, as it influences primary cilia formation and dermal papilla maintenance through noggin and sonic hedgehog signaling.
88 citations
,
May 2012 in “Human Reproduction Update” This review discusses WHO group 2 anovulation, highlighting polycystic ovary syndrome as a common cause of infertility and noting current treatment options without presenting new clinical results.
70 citations
,
February 2019 in “The journal of immunology/The Journal of immunology” This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.
53 citations
,
May 1987 in “The Lancet” The document suggests a possible link between Crohn's disease and Johne's disease and calls for more research.
49 citations
,
May 2018 in “Endocrine” This study found that only eumenorrheic polycystic ovary syndrome patients showed a temporal coupling between kisspeptin and luteinizing hormone pulsatile secretions.
49 citations
,
December 2009 in “Journal of Investigative Dermatology” This review explores the complex relationship between thyroid hormones and skin, discussing potential mechanisms and known interactions but reports no new clinical results, emphasizing the need for further research.
47 citations
,
December 2016 in “Scientific Reports” This study found that women with PMS were more likely to use suppression rather than reappraisal for emotion regulation, and increased suppression was linked to higher skin conductance levels in these women.
45 citations
,
January 2008 in “Drugs” This study found that dutasteride effectively improved urinary symptoms, reduced acute urinary retention risk, and decreased prostate volume in men with moderate to severe BPH over two years.
43 citations
,
May 1986 in “Clinics in Endocrinology and Metabolism” This review examines androgen status in male and female obesity and its influence on the metabolic syndrome, but reports no new clinical results.
39 citations
,
January 2019 in “Cells” This review discusses the molecular mechanisms of Hutchinson-Gilford progeria syndrome and evaluates current research trends, available mouse models, and prospects for developing therapies, but reports no new clinical findings.
32 citations
,
May 2010 in “Pharmacopsychiatry” This article investigates whether finasteride influences adult hippocampal neurogenesis related to depression and reports no new clinical findings; the authors suggest further research on its neurosteroid inhibition.