3 citations
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October 2018 in “Journal of cosmetic dermatology” This study found that intralesional pentoxifylline injections were effective for localized alopecia areata, with the best results observed when combined with triamcinolone acetonide.
This study reported that pentoxifylline-loaded liposomes, optimized using a statistical design method, achieved a maximum encapsulation efficiency of 84.23% and a controlled 72-hour drug release, potentially improving therapeutic delivery of the drug with limited bioavailability.
This study found that combining intralesional PTX and corticosteroids may enhance treatment outcomes for alopecia areata, with PTX showing better long-term effects compared to corticosteroids alone.
November 2023 in “PubMed” This study showed that intralesional injections of pentoxifylline may be an effective and safe alternative to triamcinolone acetonide for treating localized alopecia areata.
June 2023 in “Clinical Cosmetic and Investigational Dermatology” This report describes a 60-year-old female with pretibial pruritic papular dermatitis who showed significant improvement of skin lesions after one month of treatment with oral pentoxifylline. The authors highlight the unique clinical and histological features of PPPD and propose pentoxifylline as a potential therapy.
March 2022 in “International Journal of Health Sciences” In this animal study, topical pentoxifylline was associated with improved hair regrowth in cyclophosphamide-induced hair loss in male Swiss albino rats.
January 2026 in “Al-Azhar Assiut Medical Journal” In this study, intralesional pentoxifylline was found to be an effective and well-tolerated treatment for alopecia areata, showing significant improvements in hair loss with minimal side effects and a low recurrence rate among the 50 patients tested over 12 weeks.
October 2024 in “International Journal of Medical Arts” This study found that both intralesional pentoxifylline and intralesional corticosteroids improved hair regrowth in patients with localized alopecia areata, but intralesional corticosteroids were more effective, achieving 100% hair regrowth compared to 60% with pentoxifylline.
79 citations
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October 2003 in “PubMed” In this study, PKCepsilon transgenic mice showed increased TNFalpha shedding during skin tumor promotion, which may contribute to the development of metastatic squamous cell carcinoma.
23 citations
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February 2021 in “Dermatologic therapy” This study found that pentoxifylline plus topical corticosteroids had the highest treatment success rate for alopecia areata compared to no treatment, but the best overall treatment remains uncertain due to varying data.
18 citations
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October 2020 in “Radiation Research” This review discusses the similarities between COVID-19 and acute radiation syndrome, highlighting their shared inflammatory responses and suggesting that insights from radiation biology could inform COVID-19 research and treatment approaches; it reports no new clinical results.
5 citations
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March 2012 in “Veterinary dermatology” This case report describes a potential drug-induced localized scleroderma in a Persian cat following the application of a 'spot-on' treatment.
4 citations
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October 2023 in “Dermatology” In this study, a network meta-analysis found that treating lichen planopilaris with a combination of clobetasol, hydroxychloroquine, and N-acetylcysteine was the most effective approach, while cyclosporine, methotrexate, and some other treatments were less effective compared to hydroxychloroquine.
1 citations
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January 2008 in “Elsevier eBooks” The document concludes that various disorders can cause hair loss in dogs, each requiring different treatments, and some may heal on their own.
1 citations
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January 2006 in “Elsevier eBooks” The conclusion is that different types of hair loss in dogs and cats can be cosmetic or serious, and affected animals should not be bred.
February 2026 in “American Journal of Clinical Dermatology” This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.
April 2024 in “International journal of molecular sciences” This source reports that for treating keloids and hypertrophic scars, combination pharmacotherapy targeting multiple sites is generally more effective than using a single drug, though outcomes of individual therapies vary and the development of satisfying treatments is ongoing.
February 2024 in “Sohag Medical Journal” This review discusses the challenges in treating alopecia areata and the potential psychological impact, noting that spontaneous hair regrowth often occurs and highlighting the consideration of psychotherapy alongside treatment options; it reports no new experimental results.
January 2023 in “Figshare” This meta-analysis found that a combination of clobetasol, hydroxychloroquine, and N-acetylcysteine may be the most effective treatment approach for lichen planopilaris compared to other therapies.
January 2022 in “International journal of zoology and animal biology” This review discusses canine dermatomyositis, highlighting its genetic basis, clinical manifestations, and the need for improved treatment options, without reporting new findings.
June 2018 in “Acta Scientiae Veterinariae” This study describes three cases of dermatomyositis-like disease in mongrel dogs with compatible clinical findings and outcomes following slightly different treatment protocols.
January 2014 in “Redalyc (Universidad Autónoma del Estado de México)” This case report describes a rare instance of localized scleroderma in a cat, noting that despite treatment, the lesions remained unchanged, and the cause of pruritus was undetermined.
January 2014 in “ACTA SCIENTIAE VETERINARIAE” This case report describes a cat with localized scleroderma (morphea-like) that did not show clinical resolution or spontaneous remission after treatment, differing from previously documented cases.
October 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.
25 citations
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September 2014 in “Dermatologic Surgery” This study found that hair transplantation using round grafts improved hair growth in African American women with end-stage CCCA, showing no postoperative scarring in the donor or recipient areas.
284 citations
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November 1999 in “Neurology” This article discusses the side effects of interferon beta therapy for MS, including flu-like symptoms and autoimmune reactions, and provides guidance on their management but does not report new clinical findings.
7 citations
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May 2008 in “Journal of Veterinary Internal Medicine” This case report describes a cat suspected of experiencing systemic vasculitis as an idiosyncratic hypersensitivity reaction to fenbendazole, marking it as the first documented case in cats of this rare adverse reaction.
February 2010 in “Journal of The American Academy of Dermatology” A woman with Degos disease managed her condition for nine years with medications and had two healthy pregnancies, while a separate finding suggests a possible link between female pattern hair loss and high blood pressure.
February 1990 in “Journal of The American Academy of Dermatology” This review summarizes therapeutic advances reported in English-language literature from December 1987 to December 1988 and states no new clinical results.
177 citations
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December 2002 in “The Lancet” In this study, single fibrinogen/LDL apheresis showed a significant improvement in speech perception for patients with plasma fibrinogen concentrations over 295 mg/dL compared to standard treatment for sudden sensorineural hearing loss.