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This review found that oral and topical phosphodiesterase inhibitors and topical prostaglandin analogues are safe and effective treatments for various skin diseases, including psoriasis, atopic dermatitis, vitiligo, and alopecia.

This review discusses the use of phosphodiesterase inhibitors for alopecia, finding promising preliminary results with topical caffeine for androgenetic alopecia and telogen effluvium, but limited success in alopecia areata.

This letter to the editor comments on the association between androgenetic alopecia and increased scalp hardness, exploring the possible role of phosphodiesterase inhibitors but provides no new clinical results.

This review discusses the challenges in developing combination therapies for urological conditions and notes that regulatory requirements and financial disincentives hinder progress, without presenting new clinical findings.

This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.

This review discusses recent advancements and new approvals in the medical treatment of lower urinary tract symptoms, particularly highlighting drugs for nocturia and ongoing trials for multiple related conditions, while reporting no new clinical results.

This study found that triglyceride and energy metabolic pathways are crucial factors influencing wool fiber diameter in fine-wool Alpine Merino sheep, providing insights for enhancing wool quality.

This study found that the 15-PGDH inhibitor DPP improved endothelial function in hair-related cells exposed to DHT by reducing oxidative stress and enhancing angiogenic capacity.

This study found that phosphodiesterase inhibitors may suppress the proliferation of benign prostatic hyperplasia epithelial cells by modulating CCL5 levels in low androgen conditions.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

This study found changes in the PGI2 pathway, especially in gene and protein expression, in diabetic mice, but did not observe PGI2-dependent vasomotor dysfunction.

This study observed that PCE-DP may improve skin pigmentation by increasing epidermal turnover and inhibiting melanin uptake and inflammation in human epidermal keratinocytes.

In this study, researchers reported that the activation of EDA2R by p53 leads to p53-dependent cell death in cancer cells and is involved in chemotherapy-induced hair loss.

In this study, a risk score was developed and validated to identify patients at high risk of clinical failure after femoropopliteal peripheral vascular intervention, aiming to guide the selection of patients who may benefit from paclitaxel-coated devices or alternative strategies.

This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.

This report details a case study where a 40-year-old woman experienced allergic contact dermatitis and angioedema-like symptoms after using PPD-containing hair dye. Patch testing confirmed a positive reaction to PPD, highlighting the substance's potential to cause both T-cell and IgE-mediated hypersensitivity reactions.

This study found that the peptide derivative beta-Ala-Pro-Dab-NHbenzyl may reduce wrinkles and sebum production in human skin by inhibiting dipeptidyl peptidase 4, suggesting potential for acne and skin inflammation treatment.

This study observed that while topical drug therapy for erosive pustular dermatosis rarely leads to complete resolution, surgery may achieve remission in male patients.

This study found that PRP injections may safely improve penile curvature and PDQ scores in men with stable-phase Peyronie's Disease, although the curvature reduction observed was not enough to determine long-term clinical significance.

This review discusses how dehydroepiandrosterone (DHEA) may exert its biological effects through multiple receptors and reports no new clinical results.

This study evaluated the effect of intralesional injections of lyophilized Platelet Derived Growth Factors in 42 patients with Peyronie's disease and found significant reductions in penile curvature and plaque size, along with improvements in Peyronie's Disease Questionnaire scores, suggesting a potential treatment role.

This study found that a phosphodiesterase 3 inhibitor promoted hair growth in human dermal papilla cells and stimulated anagen induction in mice, suggesting potential as a treatment for alopecia.

In this study, researchers identified PSENEN mutations that can lead to a form of Dowling-Degos disease, characterized by follicular hyperkeratosis and an increased susceptibility to acne inversa, especially in the presence of certain trigger factors.

This study found that epidermal growth factor receptor inhibitors can induce erosive pustular dermatosis of the scalp, typically appearing sooner and affecting the scalp more extensively compared to other triggers.

Two elderly men developed scalp inflammation after using a gel for skin lesions, which healed with treatment except for some permanent hair loss.

This study found that PRP injections are safe and may slightly reduce penile curvature and improve PDQ scores in men with stable-phase Peyronie's Disease, but the changes are not significant enough to predict long-term effects.

This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.

This study found that local PGE2 injection may prevent radiotherapy-induced hair loss by protecting hair follicle cells and promoting hair follicle self-repair.

This report details the case of an 11-year-old girl with APECED syndrome carrying a unique homozygous mutation in the AIRE gene, the first of its kind documented.

DHEA therapy improves pubic hair growth and psychological well-being in young females with central adrenal insufficiency.