Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial

January 2009 in “ Yearbook of Endocrinology ”

Erica A. Eugster

dehydroepiandrosterone pubic hair growth central adrenal insufficiency DHEA

TLDR DHEA therapy improves pubic hair growth and psychological well-being in young females with central adrenal insufficiency.

The study investigated the effects of dehydroepiandrosterone (DHEA) therapy on pubic hair growth and psychological well-being in adolescent girls and young women with central adrenal insufficiency. It was a double-blind, randomized, placebo-controlled Phase III trial. The results indicated that DHEA therapy led to significant improvements in pubic hair growth compared to the placebo group. Additionally, participants receiving DHEA reported enhanced psychological well-being. The study provided evidence supporting the use of DHEA in managing symptoms associated with central adrenal insufficiency in this demographic.

View this study on linkinghub.elsevier.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial

49 citations , January 2009 in “The Journal of Clinical Endocrinology & Metabolism”

DHEA treatment helps grow pubic hair and boosts mood in girls with adrenal issues.

Related Community Posts Join

6 / 6 results

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

in Finasteride/Dutasteride 27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 9 months ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 140 upvotes 10 months ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community Please take a vitamin & hormone test

in Chat 257 upvotes 1 year ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 2 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

Similar Research

5 / 1000+ results

research Faculty Opinions Recommendation of Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial.

May 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

DHEA therapy improved pubic hair growth and psychological well-being in young females with adrenal insufficiency.

research Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial

February 2009 in “Endocrinology”

DHEA therapy improves pubic hair growth and psychological well-being in girls with central adrenal insufficiency.

research Effects of Dehydroepiandrosterone Therapy on Pubic Hair Growth and Psychological Well-Being in Adolescent Girls and Young Women with Central Adrenal Insufficiency: A Double-Blind, Randomized, Placebo-Controlled Phase III Trial

49 citations , January 2009 in “The Journal of Clinical Endocrinology & Metabolism”

DHEA treatment helps grow pubic hair and boosts mood in girls with adrenal issues.

Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

research Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

117 citations , May 2017 in “Human Reproduction Update”

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

research Congenital Adrenal Hyperplasia: A Comprehensive Review

88 citations , April 2017 in “Journal of Pediatric and Adolescent Gynecology”

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.