P-Phenylenediamine-Induced Angioedema-Like Facies: A Case Report and Review of Pathomechanisms
March 2026
in “
Indian Dermatology Online Journal
”
Studysummary This report details a case study where a 40-year-old woman experienced allergic contact dermatitis and angioedema-like symptoms after using PPD-containing hair dye. Patch testing confirmed a positive reaction to PPD, highlighting the substance's potential to cause both T-cell and IgE-mediated hypersensitivity reactions.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This case report discusses a 40-year-old woman who developed angioedema-like facies and allergic contact dermatitis (ACD) after using a hair dye containing para-phenylenediamine (PPD). The patient experienced facial swelling and erythematous, pruritic lesions, which were treated successfully with oral methylprednisolone and topical corticosteroids. Patch testing confirmed sensitivity to PPD, and elevated serum IgE and eosinophil counts suggested an IgE-mediated component. The report highlights the dual pathways (T-cell and IgE-mediated) involved in PPD reactions and emphasizes the importance of early detection and public awareness to prevent severe allergic reactions.
