Trimodal Minimally Invasive Therapy for Stable-Phase Peyronie's Disease: A Two-Center Real-Life Prospective Pilot Study

September 2025

Fausto Negri, Edoardo Pozzi, Leutrim Zahiti, Gabriele Birolini, Massimiliano Raffo, Alessia d’Arma, Francesco Montorsi, Agostino Mattei, Andrea Salonia

Platelet-Rich Plasma PRP tadalafil penile stretching Peyronie's Disease Peyronie's Disease Questionnaire Cialis

Studysummary This study found that PRP injections may safely improve penile curvature and PDQ scores in men with stable-phase Peyronie's Disease, although the curvature reduction observed was not enough to determine long-term clinical significance.

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This pilot study involving 38 patients with stable-phase Peyronie's Disease evaluated the effects of Platelet-Rich Plasma (PRP) injections on penile curvature and patient-reported outcomes. Patients received two PRP injections, followed by tadalafil and penile stretching. Results showed a median reduction in penile curvature from 55° to 45° after three months, with significant improvements in Peyronie's Disease Questionnaire (PDQ) scores. However, the changes in penile curvature were not substantial enough to predict long-term clinical significance. No adverse events were reported, suggesting PRP is a safe treatment option for improving penile morphometric parameters and PDQ scores.

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research Applications of the Regenerative Capacity of Platelets in Modern Medicine

60 citations , December 2021 in “Cytokine & growth factor reviews”

This review discusses the regenerative applications of platelet-rich plasma across various medical fields and reports no new clinical results, highlighting the need for further research into standardizing its preparation and use.

research Platelet-Rich Plasma for Androgenetic Alopecia: Does It Work? Evidence from Meta-Analysis

64 citations , March 2017 in “Journal of Cosmetic Dermatology”

This meta-analysis suggests that local injection of platelet-rich plasma for androgenic alopecia is associated with an increased number of hairs and some increase in hair thickness, though larger studies are needed for confirmation.