August 2025 in “Frontiers in Endocrinology” This study examined postmenopausal hyperandrogenism related to ovarian disease and found that specific biochemical markers can help differentiate between tumorous and non-tumorous cases, with a good level of sensitivity and specificity, supporting surgical intervention for resolution.
January 2025 in “International Journal of Unani and Integrative Medicine” This review explores hirsutism in women with PCOS, analyzing its pathophysiology and management through both modern medicine and Unani perspectives, and suggests combining these approaches for more holistic care, while calling for future research to enhance treatment efficacy and safety.
January 2025 in “Case Reports in Endocrinology” This paper discusses four rare causes of hyperandrogenism in women, emphasizing the importance of detailed biochemical testing and invasive diagnostic tools when imaging fails to identify ovarian tumors.
April 2024 in “International Journal of Advanced Multidisciplinary Research and Studies” This study outlines a multidisciplinary approach to investigate primary amenorrhea, emphasizing the necessity to consider medical history, physical examination, and potential hormonal or anatomical causes, and recommends early referral in cases of chromosomal abnormalities or persistent amenorrhea following the development of secondary sexual characteristics.
January 2024 in “Journal of surgical case reports” In this case study, researchers reported a 61-year-old postmenopausal woman with virilizing symptoms like hirsutism and voice deepening was found to have an androgen-secreting adrenal tumor, emphasizing the importance of considering this diagnosis in similar cases.
December 2023 in “JCEM case reports” In this study, researchers identified a novel genetic variant in the NR3C1 gene in a mother and her son that predicts a truncated protein, leading to glucocorticoid resistance syndrome with mild hyperandrogenic features, although no clear genotype-phenotype correlation has been established.
December 2023 in “Asian Journal of Pharmaceutical Research and Development” This research suggests that phytoestrogen-rich herbal extracts may help reduce hyperandrogenism, insulin resistance, and ovarian weight while promoting ovulation in polycystic ovarian syndrome, indicating potential for discovering new bioactive compounds.
June 2023 in “Journal of multidisciplinary sciences” This review examines the potential link between polycystic ovary syndrome and reproductive cancers, highlighting possible underlying causes as well as the ongoing debate over the cancer risk in these patients.
June 2022 in “International Journal of Health Sciences (IJHS)” This review examines the role of certain proteins in the pathogenesis of polycystic ovary syndrome and reports no new results, emphasizing the potential for future diagnostic and therapeutic advancements.
April 2022 in “Our Dermatology Online” This case report details a 40-year-old woman with idiopathic hirsutism, as she exhibited terminal hair on the left side of her chin without signs of hyperandrogenism.
January 2022 in “International Journal of Science and Research (IJSR)” This review discusses the biochemical and psychological impacts of polycystic ovary syndrome on immune functions against COVID-19 but reports no new clinical results.
July 2020 in “International Journal of Research” This review examines the development of cardiovascular risk factors related to testosterone levels in PCOS women and reports no new clinical results.
December 2015 in “Revista Chilena de Dermatología” This article discusses the dermatological manifestations of polycystic ovary syndrome and emphasizes the importance of recognizing acne, hirsutism, and alopecia for early diagnosis; it reports no new clinical results.
This study found that polycystic ovary syndrome is the most common cause of hirsutism in premenopausal Algerian women, with recommendations for thorough endocrinologic evaluations.
April 2008 in “Obstetrics, gynaecology and reproductive medicine” This article reviews the diagnosis and management of hirsutism in women, discussing its causes, assessment, and treatment options; no new clinical findings are included.
November 2004 in “John Wiley & Sons, Ltd eBooks” This chapter reviews polycystic ovary syndrome (PCOS), focusing on its definition, causes, and treatment approaches, but reports no new research findings.
June 2003 in “Obstetrical & Gynecological Survey” In this study, the size of vaginal prolapse was significantly linked to preoperative vaginal length and the length of vaginal excision following the Michigan four-wall sacrospinous suspension.
12 citations
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August 2011 in “European Journal of Endocrinology” This study found that anti-Müllerian hormone (AMH) is a valuable primary variable for classifying functional androgenization, especially in distinguishing ovarian-related groups, and supports the novel stratification system.
January 2012 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This article discusses the role of androgens in skin conditions like acne and alopecia, emphasizing combined systemic and topical therapy approaches, but it reports no new clinical outcomes.
November 2004 in “Medical Journal of Indonesia” This review discusses the impact of hormonal changes on female skin and hair loss and suggests that antiandrogenic treatments may help mitigate these effects, but reports no new clinical results.
12 citations
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March 2022 in “Frontiers in Nutrition” This review discusses the complex skin changes associated with obesity and the potential benefits of nutritional interventions for inflammatory skin diseases, without reporting new clinical results.
3 citations
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September 2025 in “Frontiers in Cardiovascular Medicine” This study reports that women with polycystic ovary syndrome, especially those with a hyperandrogenic pattern, are at a higher risk for cardiovascular disease compared to other PCOS patients, likely due to related metabolic comorbidities.
2 citations
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November 2019 in “Case reports in women's health” In this study, two women with hyperandrogenic symptoms were found to have ovarian Leydig cell tumors after selective ovarian venous sampling and salpingo-oophorectomy, leading to a decline in testosterone levels post-surgery.
2 citations
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May 2018 in “Diagnosis” This case report presents a rare instance of an ovarian steroid cell tumor in a 68-year-old female with virilism, which normalized androgen levels following surgical removal.
May 2026 in “Endocrine Connections” This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.
November 2022 in “International Journal of General Medicine” This study found that non-alcoholic fatty pancreas disease is significantly more prevalent in women with polycystic ovary syndrome, and is associated with metabolic syndrome, insulin resistance, and hyperandrogenism.
October 2022 in “Journal of Pediatric and Adolescent Gynecology” This case study observed that unilateral oophorectomy may improve severe hyperandrogenism in adolescents with PCOS, even when imaging and SVS do not indicate neoplasm.
January 2003 in “Seminars in Reproductive Medicine” This review discusses updated recommendations and recent studies on PCOS management but reports no new clinical results, questioning whether the 2018 global guideline will change practice.
254 citations
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March 2023 in “Diagnostics” This manuscript reviews current diagnostic criteria for polycystic ovary syndrome, emphasizing the need for accurate diagnosis in both clinical and research settings, but it does not provide new clinical findings.
April 2024 in “JCEM case reports” In this case study, a 44-year-old woman with an adrenal adenoma secreting both cortisol and androgens developed Cushing syndrome and significant virilization, but experienced major symptom improvement following surgical removal of the benign tumor.