Women With PCOS Have a Heightened Risk of Cardiometabolic and Cardiovascular Diseases: Statement From the Experts Group on Inositol in Basic and Clinical Research and PCOS (EGOI-PCOS) and Italian Association of Hospital Cardiologists (ANMCO)

September 2025 in “ Frontiers in Cardiovascular Medicine ”

Giovanna Geraci, Carmine Riccio, Fabrizio Oliva, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabio Facchinetti, Vittorio Unfer

PCOS Polycystic Ovary Syndrome hyperandrogenic PCOS hypertension obesity insulin resistance oral contraceptives metformin GLP-1 receptor agonists birth control pills Glucophage GLP-1 drugs

TLDR Women with PCOS have a higher risk of heart disease.

Women with Polycystic Ovary Syndrome (PCOS) face a heightened risk of cardiometabolic and cardiovascular diseases due to associated comorbidities like hypertension, obesity, and insulin resistance. A large study with 60,789 participants confirmed this significant association, particularly in women with hyperandrogenic PCOS phenotypes. The document emphasizes the importance of early diagnosis and management of cardiovascular risk factors, recommending preventive screening and personalized treatment strategies. While oral contraceptives are commonly used, metformin and GLP-1 receptor agonists may be more effective for metabolic issues. The statement is supported by expert groups, highlighting the need for comprehensive cardiovascular risk assessment in clinical practice for women with PCOS.

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4 / 4 results

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