Women With PCOS Have a Heightened Risk of Cardiometabolic and Cardiovascular Diseases: Statement From the Experts Group on Inositol in Basic and Clinical Research and PCOS (EGOI-PCOS) and Italian Association of Hospital Cardiologists (ANMCO)

September 2025 in “ Frontiers in Cardiovascular Medicine ”

Giovanna Geraci, Carmine Riccio, Fabrizio Oliva, Domenico Gabrielli, Furio Colivicchi, Massimo Grimaldi, Fabio Facchinetti, Vittorio Unfer

PCOS Polycystic Ovary Syndrome hyperandrogenic PCOS hypertension obesity insulin resistance oral contraceptives metformin GLP-1 receptor agonists birth control pills Glucophage GLP-1 drugs

Studysummary This study reports that women with polycystic ovary syndrome, especially those with a hyperandrogenic pattern, are at a higher risk for cardiovascular disease compared to other PCOS patients, likely due to related metabolic comorbidities.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Women with Polycystic Ovary Syndrome (PCOS) face a heightened risk of cardiometabolic and cardiovascular diseases due to associated comorbidities like hypertension, obesity, and insulin resistance. A large study with 60,789 participants confirmed this significant association, particularly in women with hyperandrogenic PCOS phenotypes. The document emphasizes the importance of early diagnosis and management of cardiovascular risk factors, recommending preventive screening and personalized treatment strategies. While oral contraceptives are commonly used, metformin and GLP-1 receptor agonists may be more effective for metabolic issues. The statement is supported by expert groups, highlighting the need for comprehensive cardiovascular risk assessment in clinical practice for women with PCOS.

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4 / 4 results

research Women With Polycystic Ovary Syndrome: A Review of Susceptibility to Type 2 Diabetes

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This review investigates the relationship between polycystic ovarian syndrome and the development of type 2 diabetes mellitus but reports no new clinical findings.

research Approach to Androgen Excess in Women: Clinical and Biochemical Insights

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This review outlines a diagnostic approach for identifying non-PCOS pathology in women with androgen excess, emphasizing the importance of clinical history and biochemical phenotyping but reports no new clinical results.

Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.

research Prevalence of Hyperandrogenic States in Late Adolescent and Young Women: Epidemiological Survey on Italian High-School Students

34 citations , February 2013 in “The Journal of Clinical Endocrinology and Metabolism”

This study estimates the prevalence of hyperandrogenic states in late adolescent and young females, revealing that these disorders often begin at a young age.