Risk of Abnormal Pregnancy Completing Chemotherapy for Gestational Trophoblastic Tumor

    June 2003 in “ Obstetrical & Gynecological Survey ”
    Hideo Matsui, Yoshinori Iitsuka, Kiyomi Susuka, Koji Yamazawa, Naotake Tanaka, Kazuhiko Seki, Souei Sekiya
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    TLDR After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.
    The document presents several studies conducted 20 years ago. One study on 76 women found that the Michigan four-wall sacrospinous suspension was an effective treatment for post-hysterectomy vaginal vault prolapse. Another study on 387 patients found that normal pregnancy rates can be expected after chemotherapy for gestational trophoblastic tumor (GTT), but the risk of another GTT in a subsequent pregnancy is slightly increased. It also suggested that patients should wait 12 months before attempting another pregnancy. A trial on 17 nonobese women with Polycystic Ovary Syndrome (PCOS) found that metformin reduced hyperinsulinemia and hyperandrogenism, offering an effective treatment for anovulation. A study on 36 premenopausal, hyperandrogenic women found that flutamide led to modest improvement in alopecia after 1 year. Another study on 35 ovulatory women found that the start day of clomiphene therapy for infertility does not affect oocyte quality or endometrial receptivity. Lastly, a study found that postmenopausal ovaries neither synthesize nor secrete androgens, suggesting that the adrenal gland might be the source of postmenopausal androgens.
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