Role of Polycystic Ovary Syndrome in Increasing Susceptibility to COVID-19: A Biochemical and Psychological Approach

The document explored the role of polycystic ovary syndrome (PCOS) as a comorbidity that increased susceptibility to COVID-19. It highlighted how hyperandrogenic conditions in PCOS could enhance the expression of viral receptors, such as transmembrane serine protease and angiotensin-converting enzyme-2, facilitating viral entry. Factors like obesity, insulin resistance, and Vitamin D deficiency were linked to increased hospitalization rates and impaired immune responses. Psychological aspects, including anxiety and depression, were also noted in COVID-19 patients with PCOS. The review aimed to provide insights into the biochemical and psychological mechanisms affecting COVID-19 infectivity in women with PCOS, suggesting the need for inclusive treatment options. However, it acknowledged gaps in understanding the therapeutic and molecular mechanisms of PCOS as a comorbidity in COVID-19.