Postmenopausal Ovarian Hyperandrogenism of Surgically Treated Patients: A Case Report and Scoping Review with Individual Patient's Data Analysis

August 2025 in “ Frontiers in Endocrinology ”

A Forte, Lanfranco D’Elia, Cristina Luca, Antonella Fiore, Antonio Barbato, Veronica Abate, Anita Vergatti, Nunzia Verde, Gianpaolo De Filippo, Pietro Venetucci, Maria Chiara De Angelis, Rosa Maria Di Crescenzo, Fortunata Grasso, Giuseppe Pascarella, Pietro Formisano, Attilio Di Spiezio Sardo, Rosario Pivonello, Domenico Rendina

postmenopausal ovarian hyperandrogenism ovarian tumors biochemical parameters androgens

TLDR Biochemical markers help diagnose ovarian tumors in postmenopausal women.

This study examines postmenopausal hyperandrogenism (PH) due to ovarian diseases, featuring a case report of a 60-year-old woman whose condition resolved after surgery. The scoping review analyzed 280 PH patients, distinguishing 174 tumorous from 106 non-tumorous cases. Tumorous cases showed lower BMI, LH, and FSH levels, but higher testosterone, DHEA-S, 17-OH progesterone, and estradiol levels. Specific biochemical markers were identified to differentiate between tumorous and non-tumorous cases, with no PH recurrence post-surgery. The study highlights the effectiveness of surgical treatment and the use of radiological exams for diagnosis, though its findings are limited to surgically treated cases.

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