Androgenetic Alopecia in Polycystic Ovary Syndrome: A Cutaneous Marker of Systemic Metabo-Inflammatory and Endocrine Dysfunction: A Narrative Review
May 2026
in “
Endocrine Connections
”
Studysummary This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This narrative review examines the intricate relationship between androgenetic alopecia (AGA) and polycystic ovary syndrome (PCOS), suggesting that AGA in PCOS results from a combination of systemic metabolic and hormonal dysregulation, including insulin resistance and chronic inflammation, rather than solely hyperandrogenism. It highlights the role of genetic predispositions and metabolic dysfunction in creating a vulnerable environment for hair follicles, where androgens amplify hair loss. The review emphasizes the need for a holistic, systems-level approach to treatment, addressing both cutaneous and systemic health outcomes, and calls for further research into precision-based care and regenerative therapies.
