Spironolactone

Spironolactone, a medication used for conditions such as heart failure and hypertension, has been associated with various side effects and risks. It can lead to hyperkalemia, especially in older individuals, those with renal impairment, or when combined with potassium supplements or ACE inhibitors. Studies have shown that spironolactone can be well-tolerated in some patient groups, but it has also been linked to adverse effects like gynecomastia, changes in cholesterol levels, gastrointestinal issues, and rare cases of agranulocytosis. Additionally, there is a concern for increased risk of hospitalization due to upper gastrointestinal bleeding and potential tumorigenicity. The document underscores the necessity for careful monitoring of patients on spironolactone to manage and mitigate these risks.