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This study reported discovering a novel missense variant in a case of autosomal recessive woolly hair in a 31-year-old Chinese woman, which significantly reduced secretion of the encoded protein, likely leading to disease by impairing its hydrolytic function.

This study found that P144 (Disitertide) significantly reduced collagen deposition and improved muscle organization in a rabbit model of post-radiotherapy fibrosis, suggesting potential antifibrotic effects.

Increasing TSPO in the brain may help improve memory problems.

This study demonstrated that a combination of four types of honey significantly improved hair integrity, porosity, and surface roughness after exposure to UV-A and pollution stress.

This study found that specific TRPM5 modulators are unlikely to directly affect sebaceous glands, but safe TPPO analogues may provide moderate lipogenic and anti-inflammatory effects beneficial for dry skin conditions.

This study identified ABCB6 as the first gene linked to dyschromatosis universalis hereditaria (DUH) in a large Chinese family, suggesting it plays a role in skin pigmentation.

This study found that methylprednisolone can block IgG-induced keratinocyte detachment in an animal model of pemphigus vulgaris, potentially by increasing the synthesis and modifying adhesion molecules.

The researchers reported that targeting glycoprotein 130's signaling site in animal models promoted tissue regeneration and reduced osteoarthritis progression through anti-inflammatory and protective effects.

The LTF gene may help predict and manage nonspecific orbital inflammation.

This study optimized the reaction conditions for the stereoselective hydrogenation of a compound used in manufacturing finasteride and dutasteride, improving the selectivity for the desired isomer.

In this study, clinically used preoperative skin preparations with povidone iodine and chlorhexidine gluconate did not meet FDA log-reduction standards for bacterial bioburden in a porcine model, suggesting persistent infection risks.

In this study, researchers identified exosomal miR-199a-3p as a key factor in the regulation of melanogenesis by dermal papilla cells, finding that it enhances melanocyte proliferation and melanin production, suggesting potential therapeutic targets for pigmentation disorders.

This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.

This study found that increasing a drug's lipophilicity and adding ethanol to the donor phase can enhance its delivery to the hair follicle, although the precise transport mechanism remains unclear.

This study identified compound heterozygous mutations, c.1101del and c.736 T > A, in the LIPH gene responsible for causing autosomal recessive woolly hair in a child, with c.1101del being a novel frameshift mutation.

This study found that the metabolic profile of finasteride in pigs closely matches that of humans, supporting the use of pigs for studying human drug metabolism.

This review discusses the role of PPAR-γ in the pathogenesis of primary cicatricial alopecia, including its involvement in lichen planopilaris and treatment trials using PPAR-agonists, and reports no new clinical results.

This study found that TPA induces apoptosis in pig renal epithelial cells by affecting cell cycle proteins, and activated ras can prevent this process.

Using finasteride with TIP extends time off period for prostate cancer patients.

This article explores the potential mechanisms by which polydeoxyribonucleotide (PDRN) could improve skin quality, slow aging, and enhance skin regeneration, but reports no new clinical findings.

In this study, researchers found that a composition containing mannose-6-phosphate significantly reduced the total skin pore area by 24% in women after 56 days and by 30.2% in men after 7 days, suggesting its effectiveness in improving pore appearance by targeting dermal and epidermal modifications.

This study identified new oxidative derivatives of finasteride, including a newly discovered metabolite, by using the fungus Macrophomina phaseolina.

This study validated that the 20p11 genetic locus is associated with increased risk of androgenic alopecia in the Chinese Han population, suggesting shared genetic factors between Chinese and European populations.

This study identified the genes for pyochelin siderophore biosynthesis as a novel target regulated by the heme-responsive PrrH sRNA in Pseudomonas aeruginosa.

This study suggests that using cholesterol-free liposomes, specifically PPD-Lip, as a delivery system with dutasteride may enhance the treatment of androgenetic alopecia by promoting hair regrowth in mice models.

This report details a case study where a 40-year-old woman experienced allergic contact dermatitis and angioedema-like symptoms after using PPD-containing hair dye. Patch testing confirmed a positive reaction to PPD, highlighting the substance's potential to cause both T-cell and IgE-mediated hypersensitivity reactions.