Exosomal miR-199a-3p From Dermal Papilla Cells Regulates Hair Follicle Pigmentation by Targeting POU2F1 in Melanocytes

    April 2026 in “ The FASEB Journal ”
    Anqi Yang, Ting Lü, Sen Wang … Yang Chen
    Studysummary In this study, researchers identified exosomal miR-199a-3p as a key factor in the regulation of melanogenesis by dermal papilla cells, finding that it enhances melanocyte proliferation and melanin production, suggesting potential therapeutic targets for pigmentation disorders.
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    Research cited in this study 10

    1. The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Regeneration, Tissue Repair, and the Regulation of Hair Follicle Growth Advances in experimental medicine and biology · 2025
    2. MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata International journal of molecular sciences · 2023
    3. The Role of Exosomes in Follicle Regeneration of Androgenic Alopecia Journal of Drug Delivery Science and Technology · 2023
    4. Treatment of Androgenetic Alopecia by Exosomes Secreted From Hair Papilla Cells and the Intervention Effect of LTF Journal of Cosmetic Dermatology · 2023
    5. Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022
    6. Exploring the Potential of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Alopecia Regenerative Engineering and Translational Medicine · 2021
    7. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    8. Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2018
    9. Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles Experimental Dermatology · 2017
    10. Comparative Secretome Analysis of Human Follicular Dermal Papilla Cells and Fibroblasts Using Shotgun Proteomics BMB Reports · 2012