Polydeoxyribonucleotide (PDRN) Salmon as an Anti-Aging Agent

February 2025 in “ Intisari Sains Medis ”

I Gusti Nyoman Darmaputra

polydeoxyribonucleotide PDRN A2A receptors NF-kB MAPK signaling pathways proinflammatory cytokines anti-inflammatory cytokines MMP-1 elastase melanin synthesis melanogenic gene expression tyrosinase activity salmon DNA collagen skin regeneration

Studysummary This article explores the potential mechanisms by which polydeoxyribonucleotide (PDRN) could improve skin quality, slow aging, and enhance skin regeneration, but reports no new clinical findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Polydeoxyribonucleotide (PDRN), derived from the DNA fragments of salmon sperm cells, shows potential as an anti-aging agent by improving skin quality and promoting regeneration. It works by activating A2A receptors, which inhibit the NF-kB and MAPK signaling pathways, reducing proinflammatory cytokines and enhancing anti-inflammatory cytokines. PDRN also prevents collagen degradation by inhibiting MMP-1 and elastase expression and reduces melanin synthesis by suppressing melanogenic gene expression and tyrosinase activity. These actions collectively contribute to slowing down the skin aging process.

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