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This study suggests that hepatocyte growth factor (HGF) may play a role in hair follicle neogenesis and that an HGF mimetic could enhance skin substitute development.

This study found that disrupting Sox21 in developing teeth leads to severe enamel hypoplasia, regional osteoporosis, and abnormal hair formation, with impaired dental epithelial differentiation and regulation of hair follicle cell fate.

This study found that vitamin D receptor expression is associated with proliferating keratinocytes, while retinoid X receptor α is linked to differentiating keratinocytes, suggesting differential targeting by vitamin D metabolites.

In this study, isotretinoin treatment significantly increased p53 expression in the skin of acne vulgaris patients, correlating with reduced acne severity and suggesting mechanisms for sebum suppression and side effects.

This review discusses the advancements needed for gene therapy to become commonly used in dermatology and reports no new clinical results.

p14ARF and p16Ink4a cause hair follicle stem cell aging and dysfunction.

This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.

This study found that early postnatal androgen activity affects the long-term expression of hormone receptors differently in female Wistar rats, influencing neural system programming during development.

This study found that balding dermal papilla cells show premature senescence and altered expression of stress and DNA damage markers, suggesting sensitivity to environmental stress in androgenetic alopecia.

In this study, researchers successfully generated functional and long-lived melanocytes from human embryonic stem cells, demonstrating their biocompatibility and high engraftability in mice, which may aid in developing treatments for pigmentary skin disorders.

This study found that circadian clock genes are involved in regulating the hair growth cycle, suggesting a connection between daily rhythms and the longer hair follicle cycling process.

In this study, transgenic mice expressing Msx-2 developed flaky skin with hyperproliferation and misalignment in epidermal cells, suggesting Msx-2 plays a role in skin and appendage growth control.

This study found that ginsenoside Rb1 treatment significantly reduced aging symptoms in mice by regulating cell cycle and apoptotic pathways, potentially linked to metabolic changes.

This study found that ALRN-6924, a clinical-stage dual inhibitor, can selectively protect human scalp hair follicles from paclitaxel-induced toxicity and damage by inducing transient cell cycle arrest in healthy cells without affecting cancer cells, potentially reducing chemotherapy-induced alopecia.

This study suggests that lipin-1 plays a crucial role in keratinocyte differentiation by modulating protein kinase C activity through diacylglycerol levels, with implications for skin biology.

This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.

In this study, Iris germanica L. rhizome-derived exosomes were found to reduce oxidative stress, enhance antioxidant enzyme transcription, and restore cellular function in human epidermal keratinocytes, suggesting potential protective effects against oxidative-stress-induced skin damage.

This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.

This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.

This study identified key mRNAs and lncRNAs, along with related pathways, that play potentially important roles in hair follicle development and cycling in cashmere goats.

WIF1 helps keep skin stem cells inactive to prevent excessive cell growth.

This study found that the development of Merkel cell carcinoma from hair follicles in mice can be driven by in vivo reprogramming with ATOH1 and relies on p53 loss for progression.

This article reviews how stem cell exhaustion contributes to aging, emphasizing the balance between proliferation and quiescence as crucial for long-term stem cell maintenance, but it reports no new results.

This review summarizes the role of non-coding RNAs in hair follicle regeneration and highlights potential therapeutic strategies, though it reports no new experimental results.

This article reviews in-vitro and cell-free methods for assessing the efficacy of herbal ingredients in cosmetic formulations for skin health and hair growth, but it reports no new clinical results.

This study examined dermal papilla cells from hair follicles, finding that gene expression changes linked to wound healing and stem cell activity align with hair follicle regression, which could inform strategies for hair growth and skin rejuvenation.

This study explored the diversity of melanocyte stem cell subpopulations in the hair follicles of adult female mice and identified novel groups with distinct immune privilege regulation, suggesting a heterogeneous landscape that future research should consider.

In this study, Wang et al. (2022) found that in patients with cutaneous lupus erythematosus, chronic lesions contained more senescent progenitor cells, marked by p16 and p21, than subacute lesions, suggesting a link between disease chronicity and cellular senescence.

This study found that mice with a homozygous knockout of the Ten1 gene, developed through CRISPR-Cas9-mediated exon 3 deletion, exhibited telomere shortening and symptoms consistent with accelerated aging, such as reduced lifespan, skin changes, aplastic anemia, and cerebellar hypoplasia.

This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.