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This study suggests that Artemis, particularly phosphorylated at serine 516, may have roles in hair follicle growth by influencing differentiation, proliferation, apoptosis, and cell cycling.

In this study on cultured human dermal papilla cells, researchers found that niacinamide may enhance hair growth by reducing oxidative stress-induced cell senescence and delaying catagen entry, suggesting potential applications against hair loss.

This study observed that treating basal and squamous cell carcinoma cells with platelet-rich fibrin significantly reduced cell viability and increased apoptosis-associated gene expression, suggesting potential use as adjunctive therapy for localized nonmelanoma skin cancers.

This study reported that immortalizing human dermal papilla cells using HPV16 E6/E7 oncogenes increased their proliferation and maintained their hair follicle formation capability, potentially facilitating in vitro hair growth and regeneration research.

The authors reported that 4-O-methylhonokiol decreased TGF-β1-induced cell cycle arrest and oxidative stress markers in human keratinocyte cells, suggesting a potential protective role in TGF-β1-mediated cell cycle regulation.

This study presents a new long-term 3D skin model using cells from mature donor skin, showing significant features of skin aging, such as decreased cellular proliferation and hyaluronan content.

This study observed that deleting ARNT in keratinocytes of mice reduced zigzag hair production and altered hair follicle differentiation, likely by affecting the expression of specific cyclin-dependent kinase inhibitors.

OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.

In this study, short-term finasteride treatment reduced apoptotic factors caspase-7 and IGFBP-3 in prostate cancer cells but did not significantly affect androgen receptor expression compared to placebo.

Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.

This study suggests that Houttuynia cordata extract may promote hair growth by stimulating dermal papilla cell proliferation and extending the anagen phase through enhanced energy metabolism and gene expression changes.

In a dermal Gorab knockout mouse model, this study found that Gorab mutations increase P53 protein accumulation and disrupt extracellular matrix expression, contributing to accelerated skin aging and suggesting a pathway involving epigenetic regulation.

In this experimental study, the researchers observed that Platycladus orientalis leaf extract promoted hair growth by enhancing dermal papilla cell proliferation and increasing growth factor expression, particularly through ACK1 activation and modulation of Wnt/β-catenin signaling pathways in cultured human cells and a 12-week topical application.

This study identified altered mRNA and lncRNA profiles in NS scalp tissues, highlighting CDKN2AIP as a downregulated gene involved in a ceRNA network.

This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.

This study found that Camellia japonica seed extract promotes hair growth by preventing premature cellular senescence and enhancing the activity of hair follicle stem cells in cases of pattern hair loss.

This study suggests that D-panthenol may promote hair growth by enhancing cell viability, suppressing apoptosis markers, and elongating the anagen phase in human hair follicle cells.

This study discovered that a network controlled by the gene p63 is crucial for keratinocyte differentiation and is linked to MYC through cell adhesion-related pathways.

In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.

This study found that NFI-C plays a crucial role in the transition from the telogen to anagen phase of the hair follicle cycle, affecting hair growth initiation in mice.

In this study, sandalore was found to activate OR2AT4, which inhibits senescent cell traits and restores proliferation in human keratinocytes, suggesting potential anti-aging applications.

This study found that ethanolic asiasari radix extract may induce apoptosis in G361 melanoma cells through ROS-dependent regulation of p53, suggesting potential as a medicinal option for melanoma.

This study found that in mice with deregulated β-catenin and PTEN signaling, increased follicular hyperplasia and sebaceous gland changes occur, but typical papillomas do not develop, potentially due to p21 response and reduced stem cell markers.

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.

In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.

This study suggests that lithocholic acid may enhance hair regeneration in alopecia by activating vitamin D receptors in human dermal papilla cells.

This study concluded that KLF4 is a crucial regulator of hair follicle stem cell quiescence and may work by interacting with multiple transcription factors to control related genes.

This study suggests that while cellular senescence impairs epidermal stem cells in aging, it also serves an essential role during embryonic development, highlighting its dual functional nature.

This study suggests that the hair growth-promoting effects of 4-O-methylhonokiol may be linked to its ability to modulate TGF-β-induced cell cycle arrest and oxidative stress in HaCaT cells.