Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the physiological roles of ovarian androgens in follicle development and atresia, emphasizing their contributions to polycystic ovary syndrome and normal follicle maturation but provides no new clinical results.

This review discusses hormone replacement therapy for women with premature ovarian insufficiency, strongly recommending it for symptom relief and bone protection, but notes a lack of evidence on optimal types and doses.

This review discusses various substances that can impact male fertility and stresses that products should be confirmed 'sperm-safe' through rigorous testing, not assumptions; it reports no new study results.

This review discusses the role of miRNA/mRNA regulatory networks in skin development, epidermal homeostasis, and tissue remodeling, and suggests potential for miRNA-based therapies in treating skin conditions, but reports no new clinical results.

In this study, researchers observed that hyperandrogenic PCOS patients exhibited distinct miRNA and TGFβ signaling gene expression patterns in granulosa cells, suggesting these factors may play a role in PCOS pathogenesis.

This review discusses treatments for polycystic ovary syndrome, including lifestyle changes, oral contraceptives, and various medications, and reports no new clinical findings; the authors highlight the potential of statins and inositol for managing symptoms.

This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.

This study highlights that the mammalian target of rapamycin complex 2 (mTORC2)-Akt signaling axis is essential for hair follicle stem cells to return to their niche and regenerate effectively by regulating metabolic pathways.

Researchers developed a method to detect hormone-blocking drugs in wastewater and found them in Beijing's sewage, suggesting they can survive sewage treatment.

This study found that miRNA expression profiles in follicular fluid are altered in women with PCOS, with certain miRNAs potentially useful for distinguishing patient subtypes and contributing to understanding PCOS heterogeneity.

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

This review explores lifestyle modifications for women with polycystic ovary syndrome, discussing dietary, physical, and supplementation strategies, but reports no new clinical results.

This article reviews dietary recommendations for managing polycystic ovary syndrome and provides evidence that diet changes can improve the androgen profile in affected women, but it reports no new clinical results.

This review discusses the potential dermatological applications of Dendrobium officinale polysaccharides, noting their hair growth promoting, skin moisturizing, and antioxidant effects, but reports no new clinical results.

This study found that 12 weeks of melatonin supplementation improved mental health and metabolic parameters in women with polycystic ovary syndrome compared to a placebo.

This article reviews the use of cross-sex hormonal therapy in transmen and reports that it is reasonably safe, suggesting monitoring should be frequent initially but can be less frequent over time.

This review discusses the International Evidence-Based PCOS Guidelines, which aim to improve diagnosis and management of PCOS and its associated comorbidities, noting the importance of early intervention and healthy lifestyle changes; it reports no new results.

This review discusses polycystic ovary syndrome treatments, focusing on the potential benefits and safety of herbs and phytochemicals, and reports no new clinical results.

This review discusses the pathophysiology, molecular genetics, and management of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, with no new clinical findings reported.

This study found that melatonin significantly improved metabolic and reproductive parameters in PCOS-induced rats, with effects similar to metformin.

This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.

In this study on rats, rutin showed dose-dependent improvements in hormonal, antioxidant, and lipid profiles related to polycystic ovary syndrome, with effects comparable to metformin.

This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

The document concludes that identifying the cause of amenorrhea is crucial for proper treatment.

This review discusses the challenges of using surrogate variables versus primary clinical end-points in PCOS trials and reports no new research results; the authors suggest focusing future studies on primary outcomes.

In this study, hair follicle stem cells from ND-GFP transgenic mice were observed to be pluripotent, effectively repairing peripheral nerve and spinal cord injuries in mouse models.

In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.

This study suggests that higher PDCD4 expression may play a significant role in polycystic ovary syndrome pathogenesis through its association with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis.