Therapeutic Approach for Metabolic Disorders and Infertility in Women with PCOS
August 2017
in “
Gynecological Endocrinology
”
oral contraceptives antiandrogens clomiphene citrate gonadotropins OHSS metformin inositol statins hirsutism hyperandrogenism insulin resistance anovulatory infertility birth control pills Clomid low-dose hormones ovarian hyperstimulation syndrome Glucophage inositol supplements cholesterol-lowering drugs
TLDR Lifestyle changes and weight loss are key for treating PCOS-related metabolic issues and infertility, with various medications available for specific symptoms.
The document from 2017 outlines treatments for metabolic disorders and infertility in women with PCOS, emphasizing lifestyle changes and weight loss as primary strategies. It mentions the use of oral contraceptives to regulate menstrual cycles and antiandrogens for severe hirsutism. Clomiphene citrate is the first-choice drug for anovulatory infertility, with low-dose gonadotropins as a follow-up to minimize OHSS risk. Metformin is highlighted for its effectiveness in improving insulin resistance and ovulatory performance, with a significant impact on reducing hirsutism and potentially lowering risks associated with pregnancy, though its safety during pregnancy is not fully established. Inositol is presented as a comparable alternative to metformin with fewer side effects, and statins are being considered for their potential benefits in reducing hyperandrogenism. The document concludes that a 5-10% weight loss can normalize reproductive function in overweight women with PCOS and underscores the need for further research on the long-term effects of these treatments.
