308 citations
,
December 2018 in “PLOS Genetics” This study identified three novel genetic loci associated with PCOS and found similar genetic architecture across different diagnostic criteria, with evidence suggesting genetic links between PCOS and various metabolic and psychological traits.
42 citations
,
September 2007 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with PCOS who have an exaggerated 17-hydroxyprogesterone response to buserelin exhibit more severe hyperandrogenemia, increased insulin secretion, and reduced insulin sensitivity.
July 2017 in “ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS” This case report describes a patient with a rare combination of imperfect osteogenesis and Escobar syndrome, highlighting the genetic complexity and clinical manifestations of these conditions.
June 2022 in “Evidence-based complementary and alternative medicine” This study found that acupressure on specific points improved health-related quality of life and reduced total testosterone levels and clinical symptoms in patients with polycystic ovary syndrome compared to controls.
3 citations
,
July 2025 in “BMC Research Notes” This study found that health coaching significantly improved waist circumference, physical activity, and lifestyle in infertile women with PCOS undergoing fertility treatments, although no significant difference was observed in weight change compared to routine care.
60 citations
,
May 2011 in “Endocrinology and Metabolism Clinics of North America” This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.
49 citations
,
July 2000 in “Journal of Histochemistry & Cytochemistry” This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.
1 citations
,
November 2021 in “World Family Medicine Journal /Middle East Journal of Family Medicine” This study aims to determine if an integrated early childhood development package can reduce developmental delays among two-year-old children in public health centers in Pakistan.
1 citations
,
January 2017 in “Indian Journal of Pharmaceutical Sciences” This study found that women with polycystic ovary syndrome in South India had higher body mass index, waist/hip ratio, and elevated levels of several hormones compared to controls, and waist/hip ratio may be a better risk indicator than body mass index.
6 citations
,
August 2023 in “European journal of endocrinology” This review discusses the 2023 International Guideline for PCOS assessment and management, highlighting updated evidence-based recommendations and practice points aimed at improving care and health outcomes, but notes that research quality remains generally low to moderate.
November 2023 in “Systems Biology in Reproductive Medicine” This study assessed vitamin E and a combined oral contraceptive's impact on continuous light-induced PCOS in female rats, finding they reduced testosterone levels and modified oxidative stress, suggesting benefits via melatonin-related pathways.
December 2025 in “Biomedicines” In this study, researchers identified two person-centered sexual function profiles among women, linked to physical and psychological factors, with PCOS showing greater, though not significant, presence in the dysfunction profile. The dysfunction was associated with higher adiposity and body-image distress.
4 citations
,
June 2024 in “BMC Women s Health” This study found that infertile female patients with comorbid PCOS experience increased sexual distress linked to impaired sexual function and heightened sexual pain, indicating a need for further research into related physiological and psychological aspects.
1 citations
,
January 2022 in “Pakistan BioMedical Journal” This study reported that a significant number of young women in Pakistan may unknowingly have PCOS, with many experiencing irregular periods, weight gain, and increased cravings potentially linked to dietary habits.
21 citations
,
August 2014 in “Gynecological Endocrinology” In this study, hs-CRP levels were not significantly associated with PCOS among Indian adolescent women, but showed a positive correlation with body mass index.
5 citations
,
February 2004 in “Clinical and Experimental Ophthalmology” This study presents two cases correlating the clinical appearance of adult-onset foveomacular vitelliform dystrophy with optical coherence tomography findings, describing the location of the yellow vitelliform material.
February 2025 in “Gastroenterology” Corticosteroids improved symptoms in a man with Cronkhite-Canada Syndrome.
13 citations
,
September 2008 in “Experimental and Clinical Endocrinology & Diabetes” This study compared the echocardiographic profiles of patients with polycystic ovary syndrome to those of healthy subjects using conventional methods and tissue Doppler imaging, but it reports no specific findings here.
August 2025 in “BMC Women s Health” This study found significant gaps in the knowledge, attitude, and practices of healthcare professionals in Ethiopia regarding the diagnosis of PCOS, with many relying only on ultrasonography and physical symptoms, underscoring the need for better diagnostic channels and education efforts.
April 2024 in “Journal of clinical medicine” The research observed that among Ecuadorian Andean women with polycystic ovary syndrome, classical phenotypes A and B were more prevalent and associated with higher risks of insulin resistance and metabolic disorders compared to phenotypes C and D.
1 citations
,
January 2004 in “Elsevier eBooks” This review discusses the complexities and challenges in treating polycystic ovarian syndrome and concludes that while lifestyle and insulin-sensitizing treatments show promise, randomized controlled trials are lacking.
2 citations
,
July 2012 in “Journal of Pediatric and Adolescent Gynecology” This case report describes an obese young adolescent girl with PCOS who presented with high testosterone levels and severe hyperinsulinemia, successfully treated with continuous combined oral contraceptives.
22 citations
,
September 2021 in “Journal of Personalized Medicine” The authors concluded that for women with PCOS, the COVID-19 pandemic and resulting lockdown exacerbated existing challenges, particularly impacting their mental health due to restricted healthcare access and increased uncertainty.
27 citations
,
March 2018 in “Fertility and Sterility” This study found that in Chinese women with PCOS, pretreatment with ethinylestradiol/cyproterone acetate was associated with a lower risk of gestational diabetes, pregnancy-induced hypertension, and premature delivery compared to those without pretreatment.
9 citations
,
May 2010 in “Gynecological Endocrinology” In this study, echocardiographic measures of cardiac function in women with polycystic ovary syndrome were found to be similar to those of healthy women.
2 citations
,
April 2021 in “Cureus” This study developed two highly reliable Arabic HRQoL questionnaires for evaluating quality of life in married and unmarried women with polycystic ovary syndrome.
2 citations
,
November 2020 in “Journal of Nepal Medical Association” This study observed that among Nepalese women with polycystic ovarian syndrome, menstrual irregularity was the most common symptom, and many had hormonal imbalances potentially increasing risks of cardiovascular disease and type 2 diabetes.
12 citations
,
January 2000 in “Time to knit” This study aimed to examine the association between polycystic ovary syndrome and obesity, particularly in the Arab World, but provides no results.
4 citations
,
September 2018 in “Journal of Drug Delivery and Therapeutics” This article discusses the pathophysiology and treatment of polycystic ovary syndrome and reports no new results, emphasizing the higher risk of metabolic and cardiovascular issues for affected women.
430 citations
,
July 2002 in “Journal of Endocrinology” This hypothesis paper suggests that PCOS may result from genetically determined ovarian hypersecretion of androgens, influencing hormone regulation and insulin resistance, with obesity further affecting its severity; no new clinical results are reported.