Polycystic Ovary Syndrome: Pathogenesis, Treatment, and Secondary Associated Diseases

    September 2018 in “ Journal of Drug Delivery and Therapeutics ”
    Abhishek Soni, Shivali Singla, Shubham Goyal
    Image of study
    TLDR PCOS is a common hormonal disorder in women linked to several health risks and can be managed through various treatments.
    Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation. It is often associated with insulin resistance, hyperinsulinemia, abdominal obesity, hypertension, and dyslipidemia, leading to serious long-term consequences such as type 2 diabetes mellitus, endometrial hyperplasia, and coronary artery disease. The pathogenesis of PCOS is explained as an alteration in gonadotropin-releasing hormone secretion, resulting in increased luteinizing hormone (LH) secretion, an alteration in insulin secretion and insulin action, and a defect in androgen synthesis. Treatment of PCOS includes maintaining a normal endometrium, antagonizing the actions of androgens on target tissues, reducing insulin resistance, and correcting anovulation. Women with PCOS are at higher risk for several other health conditions such as insulin resistance, metabolic syndrome, type 2 diabetes, obesity, heart disease, and high blood pressure.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community Proposed new pathogenesis model for androgenetic alopecia (AGA)

      in Research/Science  6 upvotes 2 years ago
      The conversation discusses a new model for understanding androgenetic alopecia (AGA), linking it to dietary and lifestyle factors similar to PCOS, and highlighting the role of DHT, vascular damage, and inflammation. Treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Balding without a family history

      in Chat  6 upvotes 1 week ago
      The user is experiencing hair loss without a family history and suspects stress or telogen effluvium (TE) as the cause, despite using finasteride without results. Others suggest stress, vitamin deficiencies, or other conditions could be factors, and some mention that balding can occur without a family history.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 1 year ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community Dutasteride is amazing even for women with FAGA!

      in Female  151 upvotes 3 months ago
      Dutasteride significantly improved hair health and reduced shedding for a woman with PCOS and hyperandrogenism, without causing depression or anxiety, unlike finasteride. Dutasteride also helped with PMDD symptoms and had no side effects, though it changed hair texture.

    Similar Research

    6 / 1000+ results