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This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.

This research suggests that plucked hair follicles may serve as a reliable surrogate tissue for tumor biopsies in drug development, based on a mouse model linking hair and tumor pharmacodynamic responses.

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

The study found that over-expressing ornithine decarboxylase in the outer root sheath of the hair follicle in mice increases UVB-induced tumor growth and invasive squamous cell carcinoma compared to inter-follicular epidermal keratinocytes.

This article offers a viewpoint on hidradenitis suppurativa pathogenesis, suggesting that impaired Notch signalling from γ-secretase mutations may drive inflammation and link the condition to other Th17-driven diseases.

This review covers recent developments in inner ear therapeutics and gene delivery methods but reports no new clinical results; it highlights potential strategies for treating hearing and balance disorders.

This study found that rete ridge morphogenesis in mammalian skin is directed by a BMP-dependent developmental program, which is evolutionarily distinct from other known pathways controlling the development of hair follicles, sweat glands, and fingerprint ridges.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.

This study demonstrated how cellular flows and tissue mechanics guide the topological transformations in avian skin, essential for feather follicle development from scales.

This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.

In a mouse model study, researchers found that mutations in Aire reduced alopecia areata frequency, while Notch4 mutations did not lead to the disease, likely due to proximity with a resistance gene.

This chapter reviews classic regeneration models in planarian worms and amphibian limbs, focusing on the role of stem cells, and reports no new experimental results.

This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.

This study found that hair follicles from dogs with recurrent flank alopecia regenerated and regrew hair when grafted onto mice, suggesting systemic rather than local factors may drive the condition.

This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

This study suggests that activating retinoic acid signalling can inhibit Wnt signalling and induce regression in certain skin tumors, providing potential therapeutic strategies for tumor regression.

In this study, researchers developed a polyphenol–amino acid nanozyme capable of controlled hydrogen peroxide delivery, which effectively activated hair follicles via oxidative stress in a mouse model, suggesting a potential non-pharmacological treatment for alopecia.

This review highlights recent advancements in androgenetic alopecia treatment, focusing on the dysregulated signaling pathways involved in hair follicle regeneration and exploring innovative therapeutic strategies, including small molecule modulators and gene editing technologies, which show promise in preclinical models.

This review discusses the interactions between melanocyte stem cells and their niche in hair regeneration and repair, but reports no new results; recent studies on molecular pathways are highlighted.

This study utilized a pigmented human epidermal equivalent model to incorporate melanocytes into the epidermis and found enhanced differentiation potential compared to conventional in vitro systems, reflecting in vivo cellular trajectories and highlighting melanocyte-to-keratinocyte communication pathways.

This review discusses the role of regulatory T-cells in tissue repair and regeneration across various organs and reports no new clinical results.

This study found that skin-resident Treg cells regulate hair follicle stem cell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.

This study demonstrated that engineered exosomes carrying EGF and FGF restored hair density and follicle integrity in an androgenetic alopecia mouse model by reactivating hair follicle growth factors, offering a novel therapeutic approach without immunogenic reactions or systemic toxicity.

This study identified that bone marrow-derived CD34⁺ cells act as fibroblast progenitors to enhance tissue regeneration in ischemic limbs by promoting angiogenesis through interactions with macrophages.

This study by Flores and colleagues found that the type of tumor that develops in a specific subset of epidermal stem cells is influenced by which tumor suppressor gene is deleted.

In this research, authors found that skin-resident ILCs regulate sebaceous gland function and microbial balance, emphasizing an immune-epithelia system that supports host-microbe symbiosis.

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

This study reported that NLRP3 plays complex roles in wound healing by initially promoting inflammation and delaying repair, but later enhancing structural restoration through distinct signaling pathways, highlighting its potential as a therapeutic target for controlling inflammation and regeneration phases.