Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice

    March 2026 in “ JID Innovations ”
    Christopher S. Potter, Kathleen A. Silva, John P. Sundberg
    Studysummary In a mouse model study, researchers found that mutations in Aire reduced alopecia areata frequency, while Notch4 mutations did not lead to the disease, likely due to proximity with a resistance gene.
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    Research cited in this study 7

    1. Alopecia Areata: Current Treatments and New Directions American Journal of Clinical Dermatology · 2023
    2. Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata Frontiers in immunology · 2022
    3. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    4. Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans Veterinary pathology · 2010
    5. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    6. Role of the Autoimmune Regulator (AIRE) Gene in Alopecia Areata: Strong Association of a Potentially Functional AIRE Polymorphism With Alopecia Universalis Tissue Antigens · 2002
    7. Alopecia Areata in Aging C3H/HeJ Mice Journal of Investigative Dermatology · 1994