CD34+ Cell-Derived Fibroblast-Macrophage Cross-Talk Drives Limb Ischemia Recovery Through the OSM-ANGPTL Signaling Axis

    April 2023 in “ Science Advances ”
    Yuwei Song, Junyao Yang, Tianrun Li … Juan Feng
    Studysummary This study identified that bone marrow-derived CD34<sup>+</sup> cells act as fibroblast progenitors to enhance tissue regeneration in ischemic limbs by promoting angiogenesis through interactions with macrophages.
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    Research cited in this study 3

    1. The Bright Side of Fibroblasts: Molecular Signature and Regenerative Cues in Major Organs npj Regenerative Medicine · 2021
    2. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018