CD4 Expression Controls Epidermal Stem Cell Balance

    February 2025 in “ Scientific Reports ”
    Nadine Brandes, Heidi Hahn, Anja Uhmann
    Studysummary In this study, researchers found that CD4 is expressed on murine K5<sup>+</sup> keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on nature.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Thy1 Marks a Distinct Population of Slow-Cycling Stem Cells in the Mouse Epidermis Nature communications · 2022
    2. Spreading of Isolated Ptch Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice International journal of molecular sciences · 2020
    3. Long-Term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences · 2019
    4. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    5. Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth EMBO journal · 2018
    6. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells Stem Cell Reports · 2017
    7. Defining Stem Cell Dynamics and Migration During Wound Healing in Mouse Skin Epidermis Nature Communications · 2017
    8. DMBA/TPA Treatment Is Necessary for Basal Cell Carcinoma Formation from Patched Deficient Epidermal Cells in Ptch Flox/Flox CD4Cre +/- Mice Journal of Investigative Dermatology · 2014
    9. Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development Birth defects research · 2009
    10. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    11. An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    12. Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of Whether Deletion Occurs During Embryogenesis or Adulthood Journal of Investigative Dermatology · 2007
    13. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    14. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003