TLDR Deleting Rac1 in the skin depletes stem cells and damages hair follicles.
The study demonstrated that the deletion of Rac1 in the epidermis, whether during embryogenesis or adulthood, led to stem cell depletion and significant changes in the skin, including increased proliferation, premature differentiation, and eventual loss of viable cell layers. This resulted in degeneration of sebaceous glands and hair follicles, highlighting Rac1's crucial role in maintaining epidermal stem cells and hair follicle integrity. The research noted potential influences of genetic background and incomplete deletion, and was supported by Cancer Research UK and the EuroStemCell FP6 programme.
139 citations
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August 2006 in “Molecular and Cellular Biology” Rac1 is vital for hair follicle health but not needed for skin maintenance.
421 citations
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September 2003 in “Development” Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.
182 citations
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May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
9 citations
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January 2017 in “Elsevier eBooks” Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
39 citations
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May 2010 in “Stem Cells” Ephrins slow down skin and hair follicle cell growth.
39 citations
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September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
