This study found that in sleep-deprived rats, increased 5α-reductase expression and activity in the prefrontal cortex contributed to psychosis- and mania-like symptoms, which finasteride ameliorated in a dose-dependent manner.
48 citations
,
January 2002 in “Dermatology” In this study, hair pain (trichodynia) was reported by a significant portion of patients with hair loss, but it did not correlate with the cause or activity of the condition.
3 citations
,
January 2016 in “Case reports in dermatological medicine” This report discusses a case of localized hypertrichosis that developed after an elderly male with Alzheimer's disease started oral rivastigmine therapy, suggesting a potential link between the drug and hair growth.
16 citations
,
November 2023 in “Scientific Reports” This study developed a niosomal delivery system loaded with tretinoin and bicalutamide, optimized for follicular targeting in acne management, showing promising accumulation in hair follicles in animal models.
2 citations
,
February 2016 in “Irish journal of psychological medicine” In this case report, a 54-year-old male experienced hair loss and discoloration after starting mirtazapine, with full hair regrowth and color restoration occurring within 10 weeks of stopping the medication.
January 2020 in “Indian Journal of Pharmaceutical Sciences” In this study, combining Kuntai capsules with nilestriol tablets for three months was found to reduce symptoms of perimenopausal syndrome and improve reproductive hormone levels more effectively than nilestriol alone; however, the benefits did not persist significantly beyond three months.
March 2012 in “Journal of The American Academy of Dermatology” Higher levels of certain nerve-related proteins are linked to hair loss in women with scalp pain.
33 citations
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November 2012 in “JAMA Dermatology” In this study, 14 out of 15 women with scalp dysesthesia also had cervical spine disease, and gabapentin improved symptoms for some patients.
May 2008 in “10th European Congress of Endocrinology” This study discovered that TTR is expressed in the human placenta as early as 6 weeks gestation, with increased levels in the first trimester potentially facilitating thyroid hormone delivery to the fetus.
17 citations
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May 2011 in “Movement Disorders” Finasteride significantly reduced tics and obsessive-compulsive symptoms in patients with Tourette syndrome.
14 citations
,
June 1995 in “The Journal of Clinical Endocrinology and Metabolism” 2 citations
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June 2018 in “Physiology & behavior” The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.
30 citations
,
January 2024 in “Frontiers in Pharmacology” This study identified common and previously unlisted adverse events associated with four anti-CGRP monoclonal antibodies for migraine prevention, highlighting a varied safety profile post-marketing.
April 2017 in “European Psychiatry” This case report describes a 64-year-old woman who developed delusions after starting citalopram, highlighting citalopram-induced psychosis in older adults as a potential but rare side effect.
16 citations
,
December 2012 in “The Clinical Journal of Pain” This study found that trichodynia is associated with both peripheral and central sensitization, potentially linked to hair cycle abnormalities and chronic pain through proinflammatory agents.
47 citations
,
November 1982 in “Journal of Cardiovascular Pharmacology” Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.
56 citations
,
July 2014 in “PLoS ONE” This study found that midazolam improved PTSD-associated behavioral deficits in rats through its action on the TSPO, CBR, and neurosteroidogenesis pathways.
24 citations
,
March 2009 in “Journal of the European Academy of Dermatology and Venereology” This paper highlights trichodynia as a distinguishing symptom of telogen effluvium, but it does not present new clinical findings.
February 2024 in “Health Sciences” This review discusses the non-cosmetic uses of botulinum neurotoxin A, including its effectiveness for idiopathic hyperhidrosis and potential use for androgenic alopecia, and reports no new clinical results; the authors highlight the need for more clinical trials.
October 2009 in “Nature Reviews Urology” March 2023 in “Epilepsia” This study suggests that repeated trilostane treatment increases brain allopregnanolone levels and delays epileptogenesis in rats after status epilepticus.
46 citations
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May 2011 in “Movement Disorders” This article contains additional supporting information available online but presents no new research findings.
July 2009 in “Guoji yiyao weisheng daobao” This study found that combining α 1A-blockers with Prozac was more effective for treating premature ejaculation than using Prozac alone.
10 citations
,
April 1964 in “Journal of the American Geriatrics Society” This article reviews triamcinolone acetonide as an intramuscular long-acting steroid therapy for dermatologic disorders but reports no new clinical results.
1 citations
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October 1996 in “PubMed” This study found that common side effects leading to premature removal of the Norplant contraceptive implant included uterine bleeding, amenorrhea, and headaches, suggesting the need for improved pre-insertion counseling and screening.
18 citations
,
April 2011 in “Neuropharmacology” This study found that metyrapone and etomidate provide dose-dependent anticonvulsant effects against seizures, with delayed effectiveness linked to increased neurosteroid levels.
November 2019 in “Synapse” This study found that the 5α-reductase inhibitor finasteride affected phasic and tonic GABA A receptor-mediated currents differently in the thalamic reticular and ventrobasal nuclei of mice, suggesting endogenous neurosteroid modulation of these receptors.
1 citations
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January 2013 in “Digital Scholarship - UNLV (University of Nevada Reno)” This study hypothesized that finasteride administration may increase stress-induced amphetamine locomotor sensitization due to its impact on brain reward systems involving the neurosteroid allopregnanolone.
42 citations
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December 2007 in “American Journal of Psychiatry” This study examined finasteride, a 5-alpha-reductase inhibitor, for treating a Tourette’s syndrome patient unresponsive to traditional therapy, noting its limited side effects.