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    Glossary Niche

    role of an organism within its ecosystem

    In biology, a niche refers to the role or function of an organism within its ecosystem, including its interactions with other organisms and its environment. For example, in the context of hair biology, the niche of hair follicle stem cells includes their specific location in the skin, the signals they receive from surrounding cells, and their role in hair growth and regeneration.

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    1. Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches Nature Communications · 2012 · 179 citations
    2. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015 · 173 citations
    3. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    4. Compartmentalized organization: a common and required feature of stem cell niches? Development · 2010 · 63 citations
    5. The Dynamic Duo: Niche/Stem Cell Interdependency Stem Cell Reports · 2015 · 31 citations
    6. The arrector pili muscle, the bridge between the follicular stem cell niche and the interfollicular epidermis Anatomical Science International · 2016 · 14 citations
    7. Stem Cell Competition for Niche Occupancy: Emerging Themes and Mechanisms Stem Cell Reviews and Reports · 2010 · 13 citations
    8. Niche formed by bone morphogenetic protein antagonists gremlin 1 and gremlin 2 in human hair follicles Health Science Reports · 2022 · 5 citations
    9. Aging of hair follicle stem cells and their niches Journal of Biochemistry and Molecular Biology · 2022 · 2 citations
    10. The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse Stem cell research & therapy · 2022 · 2 citations
    11. Niche work when you can get it: collagen XVII and the melanocyte stem cell Pigment Cell & Melanoma Research · 2011 · 2 citations
    12. Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to its Formation and Is Progenitor Dependent bioRxiv (Cold Spring Harbor Laboratory) · 2018 · 2 citations
    13. A notch above bowl: Specification of niche cells in the Drosophila testis ScholarlyCommons (University of Pennsylvania) · 2011 · 1 citations
    14. Niche-dependent immunometabolic regulation of tissue repair and regeneration Immunity & Inflammation · 2026
    15. Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies Cell Communication and Signaling · 2026
    16. From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization Frontiers in Cell and Developmental Biology · 2026
    17. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    18. 1387 Identifying the key niche signals for hair follicle formation Journal of Investigative Dermatology · 2018
    19. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    20. What are the recommended treatment options for male pattern baldness according to NICE guidelines? Open MIND · 2026
    21. What are the recommended treatment options for male pattern baldness according to NICE guidelines? Zenodo (CERN European Organization for Nuclear Research) · 2026
    22. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations
    23. Stem cell dynamics in the hair follicle niche Seminars in Cell & Developmental Biology · 2013 · 135 citations
    24. Micropatterned dermal–epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis Acta Biomaterialia · 2013 · 65 citations
    25. Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration <i>in vivo</i> The EMBO Journal · 2019 · 44 citations
    26. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018 · 43 citations
    27. Cell Enriched Autologous Fat Grafts to Follicular Niche Improves Hair Regrowth in Early Androgenetic Alopecia Aesthetic Surgery Journal · 2020 · 8 citations
    28. Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair Nature Communications · 2023 · 4 citations
    29. The Disturbed Microbial Niches of Itchy Scalp Journal of Cosmetic Dermatology · 2025 · 1 citations
    30. Nutritional Niche Construction and Local Adaptation: The Aquatic Resource-Driven Hypothesis of EDAR V370A in East Asia Zenodo (CERN European Organization for Nuclear Research) · 2026