Neoplasms Bypass Immune Evasion via Hair Follicle Residence

    April 2016 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Bradley J. Kubick, Dennis R. Roop
    TLDR Neoplasms hide in hair follicles to avoid the immune system.
    The study investigated how neoplasms evade immune detection by residing in hair follicles. Using a genetically-engineered mouse model with inducible Kras-driven carcinogenesis, researchers observed that in immunocompetent mice, transformed cells persisted exclusively in hair follicles, suggesting these follicles provide immune privilege. This immune privilege was lost when hair follicles exited the anagen phase. The findings indicated that the hair follicle cycle might be a potent anti-tumor mechanism and that targeting long-lived, niche-protected neoplasms could be a viable strategy for cancer prevention.
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