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research Indian Hedgehog Controls Proliferation and Differentiation in Skin Tumorigenesis and Protects against Malignant Progression

15 citations , July 2013 in “Cell Reports”

This study reported that Indian hedgehog (Ihh) signaling plays a crucial role in regulating tumor progression and metastasis in epithelial cancers, with Ihh deficiency leading to increased malignancy and metastasis in mice.

research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

45 citations , September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that deleting β-catenin in epidermis-specific VDR knockout mice did not prevent UVB-induced skin tumors, indicating β-catenin does not compensate for VDR's role in tumor suppression.

research The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor

16 citations , August 2021 in “Tumor Biology”

This review discusses the dual role of the TMPRSS2 gene in coronaviral lung infection and prostate cancer, cautioning against TMPRSS2 inhibitors for early prostate cancer due to potential pro-inflammatory effects.

research Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation.

March 2020 in “The Egyptian Journal of Histology”

This study found that topical olive oil may protect mice skin from damage caused by electromagnetic radiation, particularly when applied before exposure, by mitigating oxidative, inflammatory, and heat shock stress factors.

research 089 Neoplasms bypass immune evasion via hair follicle residence

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that hair follicles may provide a safe space for tumor cells in mice, suggesting a potential target for cancer prevention during the dormant phase of tumor development.

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Community Join

5 / 416 results

community Help Me I used too much essential oils.

7 upvotes 2 years ago

A user mixed peppermint, rosemary, and castor oil and applied it to their scalp, causing excessive hair shedding. They're concerned about permanent hair loss, while another user shared their experience of using undiluted rosemary oil without any major issues.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

14 upvotes 2 years ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community L'Oreal working on Hair Cloning - Poster Presentation

20 upvotes 6 years ago

L'Oreal is working on hair cloning, with multiple companies using similar techniques, making hair cloning likely by 2030. The conversation expresses optimism about the progress and potential affordability of hair cloning solutions.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

737 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Hair loss research is a money grab

227 upvotes 10 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

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Learn

9 / 801 results

learn Vascular Endothelial Growth Factor

learn Thymosin Beta 4

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Sulforaphane

How does sulforaphane help protect hair follicles from inflammation and damage? Sulforaphane may protect hair follicles by reducing inflammation and oxidative stress.

learn Vitis vinifera

Does Vitis vinifera help protect hair follicles from damage? Vitis vinifera may protect hair follicles due to its antioxidant properties.

learn Scalp Micropigmentation

How can I protect my scalp from sun exposure after a scalp micropigmentation treatment? Wear a hat or high-SPF sunscreen to protect your scalp from sun exposure.

learn PP405

Did you know PP405 peptides can help protect your follicles from DHT? PP405 is not a peptide and does not block DHT: it is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier, aimed at waking dormant follicles. Its registered Phase 2 trial (NCT06393452) measured safety and tolerability in 78 adults with pattern hair loss; it is not approved and not for sale.

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