17 citations
,
June 2020 in “Animals” This study identified differentially expressed mRNAs and lncRNAs in Hu sheep hair follicles, suggesting certain genes and pathways are involved in the development of wool curvature patterns.
10 citations
,
May 2018 in “Cell death discovery” This study found that the interaction between heat shock protein 90 and lamin A/C is crucial for the growth, migration, and self-aggregation of dermal papilla cells, suggesting a potential role in alopecia areata mechanisms.
October 2025 in “Animal Bioscience” This study identified important lncRNAs and genes associated with cashmere shedding in goats and explored their regulatory interactions, providing insights into the molecular mechanisms that may underlie this phenomenon.
January 2023 in “Research Square (Research Square)” This study identified m6A-related genes, particularly IGF2BP3, as significantly up-regulated in keloid patients, potentially implicating them in the condition's molecular mechanisms and suggesting targets for therapy.
November 2025 in “Clinical Cosmetic and Investigational Dermatology” This study found that a combination of five medicinal plants traditionally used in Chinese medicine significantly improved skin repair and delayed aging markers in laboratory models, suggesting synergistic anti-aging effects over individual ingredients.
187 citations
,
April 2019 in “npj Regenerative Medicine” This study found that hMSC secretomes from umbilical cord Wharton's jelly had the most potent angiogenic effects, whereas those from adipose tissue demonstrated the weakest angiogenic potential.
24 citations
,
April 2020 in “Cells” This study in cashmere goats found that DNA methylation levels were lower during hair follicle differentiation compared to induction, suggesting it plays a critical role in gene regulation for hair morphogenesis.
December 2025 in “Frontiers in Veterinary Science” This study found that PT-LCG extends hair follicle activity and promotes continuous cashmere growth by enhancing lipid synthesis, remodeling the extracellular matrix, and modulating inflammatory signaling, offering insights into improving cashmere yield and quality through molecular breeding.
39 citations
,
December 2018 in “Methods in molecular biology” This review discusses the data resources and computational models used in drug repositioning, highlighting their role in discovering unknown drug mechanisms and reports no new empirical results.
31 citations
,
October 2016 in “PLoS ONE” This study suggests that UMPP activation is a key signaling pathway in differentiating primary and secondary hair follicles in cashmere goats.
25 citations
,
August 2017 in “Animal Biotechnology” This study identified and characterized several long noncoding RNAs in Cashmere goats, revealing complex regulatory roles in hair follicle development and growth, particularly within the Wnt signaling pathway.
24 citations
,
November 2021 in “PLoS ONE” In this study, fractional laser treatment was observed to reverse age-related gene expression changes in skin and enhance dermal remodeling, further improved by multiple treatments.
23 citations
,
February 2015 in “International Journal of Molecular Sciences” This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.
11 citations
,
April 2013 in “Journal of Proteomics” This study identified proteins that are differentially expressed in balding versus non-balding dermal papilla cells, potentially aiding the understanding and treatment of androgenetic alopecia.
7 citations
,
June 2024 in “Communications Medicine” In this study, researchers analyzed spaceflight data from various sources and found that skin issues during spaceflight are linked to DNA damage, mitochondrial dysregulation, and gene alterations, while also highlighting the skin's adaptability post-flight.
4 citations
,
July 2025 in “Frontiers in Immunology” This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
March 2026 in “The Indian Journal of Animal Sciences” This study on Indian dromedary camel breeds investigated the KRTAP7 protein, finding all four breeds shared an identical gene sequence, with 13 phosphorylation and glycosylation sites influencing hair characteristics, alongside predicted interactions with other biosynthesis-related proteins.
July 2025 in “Scientific Reports” In this study, researchers identified six novel prognostic biomarkers for bladder cancer and developed a predictive model that effectively stratifies patients into high-risk and low-risk groups based on immune cell infiltration differences and gene expression.
July 2022 in “Research Square (Research Square)” This study found that miR-23b and miR-133 significantly reduce mRNA and protein levels of specific target genes involved in Merino sheep hair follicle development, providing insight into molecular breeding for fine wool production.
12 citations
,
June 2017 in “Cell Cycle” This study observed that 5% minoxidil topical foam alters gene expression and signaling pathways in the scalp, providing insights into its mechanism of action in men with androgenetic alopecia.
6 citations
,
September 2019 in “Archives of Dermatological Research” In this study, researchers identified 32 differentially expressed genes involved in androgenetic alopecia, with down-regulated genes associated with Wnt and TGF-beta signaling and up-regulated genes linked to oxidative stress pathways.
62 citations
,
September 2014 in “PLoS ONE” This study identified distinct human and bacterial protein profiles in sebaceous follicular casts, with acne samples showing proteins linked to inflammation and normal samples showing proteins involved in stress protection.
25 citations
,
October 2018 in “PloS one” This study explored hair follicle gene expression in Inner Mongolia Cashmere goats and identified potential regulators of the transition between growth phases, including IL17RB and ZNF genes.
11 citations
,
June 2017 in “Journal of cell science” In this study, researchers found that AGD1 is crucial for membrane recruitment during root hair development in Arabidopsis thaliana, with its pleckstrin homology domain essential for targeting specific plasma membrane regions.
9 citations
,
February 2019 in “BMC cancer” This study found that M30 may protect against cyclophosphamide-induced alopecia in mice by enhancing hair growth and preventing abnormal hair, suggesting its potential as a treatment.
8 citations
,
January 2015 in “Genetics and molecular research” This study identified four proteins that differ between Type III and non-Type III hair in Yangtze River Delta white goats, contributing to understanding the development of high-quality brush hair.
8 citations
,
July 2011 in “Animal science journal” The researchers reported that keratin 33A is a structural protein specific to goat cashmere hair, with increased winter expression in high-cashmere-producing breeds.
7 citations
,
January 2020 in “Scientific Reports” This study identified differentially expressed miRNAs between the telogen and anagen phases of hair growth in Wan Strain Angora rabbits, contributing to understanding miRNA-mediated regulation of rabbit hair follicle cycling.
6 citations
,
April 2022 in “Frontiers in cell and developmental biology” This study identified differentially expressed proteins and pathways potentially involved in wool bending in Zhongwei goats, with specific genes like COL6A1 and CRNN emerging as important candidates in this process.
6 citations
,
January 2017 in “Journal of toxicologic pathology” This study suggests that the patchy thickening and reddish discoloration in rabbit skin during the hair cycle may be due to large anagen-phase hair follicles compressing the dermis and increased blood vessels causing redness.