Comprehensive Analysis of Differences in Cashmere Production Performance in Liaoning Cashmere Goats Using Metabolomics and Transcriptomics

December 2025 in “ Frontiers in Veterinary Science ”

Bing De Luo, Meiqi Wang, Di Han, Chunqiang Wang, Wei Ma

hair follicle lipid synthesis extracellular matrix inflammatory signaling IL-17 pathway follicular microenvironment transcriptomic analysis metabolomic analysis

Studysummary This study found that PT-LCG extends hair follicle activity and promotes continuous cashmere growth by enhancing lipid synthesis, remodeling the extracellular matrix, and modulating inflammatory signaling, offering insights into improving cashmere yield and quality through molecular breeding.

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This study investigates the molecular mechanisms behind prolonged hair follicle activity in Liaoning cashmere goats (PT-LCG) using transcriptomic and metabolomic analysis. It suggests that PT-LCG maintains continuous cashmere growth by enhancing lipid synthesis and storage, remodeling the extracellular matrix for structural support, and modulating inflammatory signaling, particularly the IL-17 pathway, to sustain follicular microenvironment homeostasis. These insights could inform molecular breeding strategies to enhance cashmere yield and quality.

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