March 2014 in “Medicina cutánea ibero-latino-americana” Melatonin applied to the scalp helps increase hair density in people with early hair loss.
349 citations,
January 2005 in “The FASEB journal” Human skin can make serotonin and melatonin, which help protect and maintain it.
208 citations,
December 2003 in “Journal of Investigative Dermatology” Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.
199 citations,
April 2010 in “Nature” A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.
175 citations,
November 2009 in “PLOS ONE” Women look young for their age due to larger lips, less sun damage, and genes that prevent gray hair and wrinkles.
127 citations,
July 1996 in “Journal of The American Academy of Dermatology” Minoxidil shortens baldness from chemotherapy by 50.2 days without significant side effects.
120 citations,
August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.
95 citations,
July 2010 in “Genes & development” Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.
80 citations,
April 2011 in “Plant physiology” White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.
76 citations,
June 2015 in “Journal of biomedical science” Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
62 citations,
July 2018 in “Lasers in Medical Science” LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.
54 citations,
May 1977 in “The Journal of Pediatrics” Minoxidil helps lower high blood pressure in kids, but can cause fluid retention and hair growth.
52 citations,
March 2010 in “British Journal of Dermatology” Alopecia areata shows a unique type 1 interferon signature, suggesting potential treatment by targeting this pathway.
47 citations,
April 2012 in “The Plant Journal” Phosphorylation of certain parts of the PIN3 protein is crucial for its role in plant root growth and response to gravity.
45 citations,
February 2005 in “Steroids” Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.
38 citations,
February 2011 in “Annals of Oncology” Men who experienced baldness at age 20 may have double the risk of getting prostate cancer.
36 citations,
January 2019 in “Nature communications” High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.
28 citations,
January 2012 in “Biological & pharmaceutical bulletin” Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.
26 citations,
July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
25 citations,
October 2018 in “PloS one” Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.
25 citations,
April 2015 in “Journal of Investigative Dermatology” GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.
22 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Fisetin, a type of polyphenol, may help hair grow by increasing certain protein activities in cells.
20 citations,
November 2019 in “Stem Cells” Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.
20 citations,
September 2019 in “Nanomaterials” A portable device can create nanofibers to improve the appearance of thinning hair better than commercial products.
20 citations,
January 2003 in “Chemical and Pharmaceutical Bulletin” The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.
19 citations,
April 2015 in “Developmental Dynamics” The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.
19 citations,
July 2006 in “Physiology & Behavior” Finasteride slows down motherly behavior in first-time pregnant rats.
18 citations,
October 2017 in “PLOS ONE” The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.
17 citations,
November 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology” Finasteride helps brain function in rats with liver-related brain issues.
16 citations,
March 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The Notch signaling pathway helps in mouse hair development through a noncanonical mechanism that does not rely on RBPj or transcription.