10 citations
,
December 1991 in “Annals of the New York Academy of Sciences” This study found that minoxidil increases the expression of a reporter gene linked to hair growth in cultured hair follicles from transgenic mice, suggesting a potential model for studying hair biology.
10 citations
,
July 1980 in “British Journal of Dermatology” This study observed that applying polyamines to the skin of hairless mice stimulates thymidine incorporation, suggesting polyamines may play a role in DNA synthesis control in the epidermis.
9 citations
,
December 2023 in “Journal of Neuroimmune Pharmacology” This study found that systemic administration of NDP-MSH, a melanocortin receptor agonist, provided neuroprotective effects on dopaminergic nigrostriatal neurons in a mouse model of Parkinson's disease, reducing neuroinflammation and suggesting a role for regulatory T cells in these neuroprotective effects.
9 citations
,
July 2008 in “Oncology Reports” In this study, TC-1 cells, resembling stromal cells formed by epithelial-mesenchymal transition, significantly affected the behavior of normal human keratinocytes, supporting the role of stromal cells in tumor progression.
8 citations
,
July 2019 in “Journal of Molecular Neuroscience” 8 citations
,
September 2011 in “Scanning” This study found that multiphoton microscopy effectively visualizes the microstructure of in vivo mouse skin, offering a clear view of various skin layers and components like corneocytes and collagen fibers.
7 citations
,
October 2022 in “Development” This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.
7 citations
,
January 2020 in “Frontiers in Pharmacology” This study found that the combination of epidermal growth factor and Jagged1 significantly stimulated hair growth in mice with androgen-suppressed conditions, suggesting potential therapeutic implications for androgenetic alopecia.
7 citations
,
May 2010 in “Drug Delivery” This study found that retinoic acid pre-treatment enhanced the efficiency of gene transfer into mouse skin for potential therapeutic applications.
7 citations
,
December 2006 In this study, oral Tribulus terrestris extract significantly increased MSH expression in mouse hair follicle melanocytes, suggesting enhanced melanocyte activity and migration.
7 citations
,
January 1976 in “International Journal of Environmental Studies” This study found that applying a mix of cholesterol and Tween 60 detergent to mouse skin significantly reduced epidermal cell mitotic activity.
7 citations
,
March 1931 in “Experimental Biology and Medicine” This study found that both rats and mice on iron-deficient diets developed symmetrical hair loss within two months.
6 citations
,
February 2019 in “Scientific reports” This study demonstrated that allopregnanolone administration caused significant scratching in atopic dermatitis mice, and ethanol-induced scratching may be linked to increased brain allopregnanolone levels.
6 citations
,
August 2015 in “Acta histochemica” In this study, lysozyme was found to promote vibrissae follicle growth in vitro by enhancing the hair-inductive capacity of dermal papilla cells.
6 citations
,
August 2014 in “Toxicologic pathology” This study found that prolonged inhibition of DGAT1 in mice and dogs led to atrophy of sebaceous glands, with mice also experiencing alopecia, suggesting potential skin-related risks for humans using DGAT1 inhibitors.
6 citations
,
January 2013 in “Experimental dermatology” This study found that bimatoprost, when applied daily at a 0.03% concentration, promoted significant hair growth in C57/black 6 mice, including earlier and faster regrowth of shaved fur.
6 citations
,
November 1960 in “Experimental Biology and Medicine” In this study, despite morphological differences in the hair growth cycle stages, the lipid composition of the epidermis and dermis showed no significant variation, though water content and cholesterol levels differed between these skin layers.
5 citations
,
September 2024 in “International Journal of Molecular Sciences” This study used a 3D bioprinted human lung cancer model in a mouse phantom to demonstrate a selective cytotoxic effect of X-rays on tumor cells, revealing differences from 2D cell models.
5 citations
,
August 2023 in “G3 Genes Genomes Genetics” This study developed an improved reference genome for the African spiny mouse using long Nanopore sequencing reads, potentially aiding future research into the species' remarkable tissue regeneration capabilities.
5 citations
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March 2023 in “Journal of the American Association for Laboratory Animal Science” In this study, the researchers observed that both standard body and facial depilatory creams caused significant skin injury in mice, with varying effects depending on the mouse strain and exposure time, although both formulations were effective for hair removal.
5 citations
,
April 2022 in “Cell Biology International” This study found that JAM-A modification in mouse wound models significantly promoted wound healing and fibroblast proliferation, potentially linked to increased levels of growth factors bFGF and EGF.
5 citations
,
June 2019 in “British Journal of Dermatology” No results are provided in this article as it lacks an available abstract, making it unclear what effects apremilast and tofacitinib have in a humanized mouse model of alopecia areata.
5 citations
,
March 1993 in “The Journal of Cell Biology” This study concluded that the increase in NGF mRNA levels during mouse whisker pad development is influenced by soluble factors produced within the tissue, rather than linked to epidermal differentiation.
4 citations
,
May 2025 in “npj Parkinson s Disease” This study identified peripheral myeloid cells as the earliest dysregulated immune cells in PINK1 KO mice with Parkinson’s-like symptoms following intestinal infections, suggesting that PINK1 regulates gut immune functions linked to early Parkinson’s disease mechanisms.
4 citations
,
July 2024 in “Animals” The researchers reported an optimized depilation procedure using cold wax and an extra skin protection step that minimizes injury in mice, revealing similar hair cycle kinetics across strains and supporting the use of Sv129 and B6129F1 mice in hair growth studies.
4 citations
,
August 2023 in “Nature Communications” In this study, researchers observed that the combination of hair progenitors and their micro-niche changes every three days in mouse zigzag hair, and disruptions in specific genes affected this rhythm, highlighting the importance of this periodic change for normal hair morphology.
4 citations
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April 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study presents an improved reference genome for the African spiny mouse, which may aid in understanding its tissue regeneration at the molecular level.
4 citations
,
February 2020 in “Cell & tissue research/Cell and tissue research” This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.
4 citations
,
June 2002 in “Veterinary Dermatology” In this study, prenatal exposure to all-trans-retinoic acid in pregnant mice resulted in increased BrdU-positive nuclei in hair bulbs without altering hair follicle morphogenesis, suggesting potential for non-teratogenic studies on skin diseases.
3 citations
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January 2024 in “Frontiers in Endocrinology” This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.