research Application of Mesenchymal Stem Cells for Anti-Senescence and Clinical Challenges
Mesenchymal stem cells could help treat aging-related diseases better than current methods.
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research Anti-Aging Potential of Platelet Rich Plasma: Evidence from Osteoarthritis and Applications in Senescence and Inflammaging
PRP may help with aging and osteoarthritis, improving tissue repair and reducing surgery risk.
research CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/Beta-Catenin Pathway
CRABP2 helps increase the growth of cells important for hair growth by activating a specific growth pathway.
research Gellan Gum-Based Hydrogels Support the Recreation of the Dermal Papilla Microenvironment
Gellan gum hydrogels help recreate the environment needed for hair growth cell function.
research Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome
The article reviews current methods and challenges in hair regeneration using cells derived from human hair follicles, focusing on the complex interaction between mesenchymal and epithelial cells. It highlights the potential of dermal papilla (DP) and epithelial stem cells (Epi-SCs) in generating new hair follicles but notes difficulties due to gene loss during cell culture and insufficient cell numbers. Techniques such as 3D cultures, signaling pathway activation, and the use of small molecules or exosomes are explored to restore the hair-inducing ability of DP cells. Despite advancements, challenges remain in maintaining cell inductivity and creating a conducive microenvironment for hair growth, emphasizing the need for improved methods to achieve functional and cycling hair follicles using only human cells.
research Deep Hair Phenomics: Implications in Endocrinology, Development, and Aging
A new tool can analyze hair to detect changes due to hormones, genetics, and aging.
research Analysis of Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep
Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.
research Cellular Therapeutics and Immunotherapies in Wound Healing – On the Pulse of Time?
Cellular and immunotherapies show promise for healing chronic wounds but need more research.
research SP1 and KROX20 Regulate the Proliferation of Dermal Papilla Cells and Target the CUX1 Gene
SP1 promotes and KROX20 inhibits hair cell growth by affecting the CUX1 gene.
research Repurposing of Various Current Medicines as Radioprotective Agents
Some existing medicines show promise as safe treatments to protect against the side effects of radiation therapy.
research Cells, Growth Factors and Biomaterials Used in Tissue Engineering for Hair Follicles Regeneration
Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.
research Molecular and Spatial Landmarks of Early Mouse Skin Development
The research maps the complex development of early mouse skin, identifying diverse cell types and their roles in forming skin layers and structures.
research Stromal Re-Organization in Hair Follicle Development and Cancer Suppression
Activating Sonic Hedgehog signaling in cancer stroma may help treat basal cell carcinoma.
research Generation of iPS-Derived Model Cells for the Analysis of Hair Development
Researchers created a cell model to study hair growth and test hair-growth drugs.
research Site of Beige and Leaden Pigment Gene Expression Determined by Recombinant Embryonic Skin Grafts and Aggregation Mouse Chimaeras Employing Sash Homozygotes
Beige and leaden pigment genes act within melanocytes, affecting pigment patterns.
research Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin
Three specific proteins can turn adult skin cells into hair-growing cells, suggesting a new hair loss treatment.
research Downregulation of Lhx2 Markedly Impairs Wound Healing in Mouse Fetus
Turning off the Lhx2 gene in mouse embryos leads to slower wound healing and scars.
research Diversity of Adult Stem Cell Niches in the Dermal Compartment of Skin
The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.
research Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells
Certain genes are more active in baby scalp cells and can help grow hair when added to adult mouse skin cells.
research Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State
Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.
research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation
Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
research The Hair Follicle as a Dynamic Mini-Organ
Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
research Multi-Scale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma
The research created a detailed map of skin cells, showing that certain cells in basal cell carcinoma may come from hair follicles and could help the cancer grow.
research The Control of Hair Growth: An Overview
Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.
research Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta
Targeting TGFβ can improve skin immunity in older people.
research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Regulation of Masculinization: Androgen Signaling for External Genitalia Development
Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.
research Molecular Biology of Hair Morphogenesis: Development and Cycling
Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.
research An In Vitro Model for the Study of Human Hair Growth
Researchers created a lab model to study human hair growth, showing it can grow and self-regulate outside the body.
research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program
The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.