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    Evolution of Long Scalp Hair in Humans

    January 2025 in “ British Journal of Dermatology ”
    Lo‐Yu Chang, Maksim V. Plikus, Nina G. Jablonski, Sung‐Jan Lin
    Studysummary This study proposes that the ability of humans to grow long scalp hair is linked to the evolutionary adjustment of molecular checkpoints that regulate the hair growth cycle, potentially influenced by its roles in communicating age, maturity, and social signals.
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    Research cited in this study 36

    1. Signaling by Senescent Melanocytes Hyperactivates Hair Growth Nature · 2023
    2. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide Toward More Effective Prevention and Hair Follicle Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Human Scalp Hair as a Thermoregulatory Adaptation Proceedings of the National Academy of Sciences · 2023
    4. A Homozygous Missense Mutation in the Fibroblast Growth Factor 5 Gene Is Associated with the Long-Hair Trait in Angora Rabbits BMC genomics · 2023
    5. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    6. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    7. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    8. Telogen Effluvium: A Review of the Literature Cureus · 2020
    9. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    10. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    11. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration Cell Stem Cell · 2018
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    20. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
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    22. The Human Hair Follicle, A Bistable Organ? Experimental Dermatology · 2012
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    27. Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats Journal of Heredity · 2007
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    29. Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen American Journal of Pathology · 2003
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    31. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    32. The Nutritional Biochemistry of Wool and Hair Follicles Animal Science/Animal science · 2000
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    Related research 7

    1. Hair Loss (Alopecia or Baldness) 2018
    2. A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth Experimental Dermatology · 2018
    3. Treatments of Hereditary Hair Loss (Alopecia) 2018
    4. Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    5. Evaluation of Hair Cycle and Epidermal Turnover Nishi Nihon hifuka · 2001
    6. Treatment of Hair Loss The New England Journal of Medicine · 1999
    7. Disorders of Hair Growth: Diagnosis and Treatment McGraw-Hill eBooks · 1994