7 citations
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March 1931 in “Experimental Biology and Medicine” This study found that both rats and mice on iron-deficient diets developed symmetrical hair loss within two months.
This study observed that activating the Wnt/β-catenin pathway enhances hair follicle stem cell proliferation and differentiation, promoting hair growth and wound healing, and demonstrated the potential for outer root sheath transplants to aid skin repair, although challenges remain for clinical application.
1 citations
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February 2016 in “Cell Transplantation” In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This summary from the source provides an overview of the Soulflower brand, noting their focus on natural, cruelty-free, and handcrafted beauty products using plant-based ingredients, and highlights the availability of a promo code HPK50 for discounts, encouraging a shift towards cleaner self-care routines without chemicals.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This source describes Soulflower, an Indian brand specializing in natural, cruelty-free beauty products, emphasizing hair and skincare while offering discounts with the HPK50 promo code to make sustainable beauty more affordable.
July 2025 in “Genome biology” This study highlighted the effectiveness of HT-scCAT-seq as a tool for understanding gene regulation in single cells, offering insights into embryonic skin development and proposing a framework for exploring regulatory mechanisms in various biological and disease contexts.
31 citations
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April 2016 in “Nature communications” This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.
November 2023 in “npj regenerative medicine” This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.
January 2023 in “Pharmaceutics” In this study, researchers developed a new topical atraric acid formulation, AA-TF#15, which showed a significantly higher drug penetration and increased hair regrowth in mice compared to minoxidil and finasteride treatments, suggesting its potential effectiveness for treating scalp androgenic alopecia.
23 citations
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August 1975 in “Experimental Biology and Medicine” This study found that supplementing pregnant and lactating mice with high dietary copper improved survival and physical traits in mice carrying the crinkled mutation, suggesting copper's role in modulating gene expression.
January 2022 in “Mammalian Genome” This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.
33 citations
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December 2004 in “Differentiation” In this study, mouse amnion epithelium was successfully transformed into skin and hair follicles when associated with hair-forming dermis, revealing the necessity of specific influences for follicle formation.
August 2022 in “Biomedicines” In this study of mouse embryos, the researchers found that the expression of the Lhx2 gene plays a significant role in wound healing and may promote scar formation in later stages of development.
159 citations
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October 2015 in “Science Advances” This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.
17 citations
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December 2010 in “Journal of Investigative Dermatology” This study found that higher levels of the protein Flii were associated with enhanced hair follicle regeneration and longer hair fibers in a mouse model.
March 2016 in “Institutional Repositories DataBase (IRDB)” This study discusses the effects of collagen hydrolysates and the dipeptide Pro-Hyp on gene expression related to hair and epidermis development in mouse skin and reports no new clinical results.
October 2025 in “Indian Dermatology Online Journal” In this case report, an elderly woman was diagnosed with tinea capitis and eyebrow involvement, which was initially misdiagnosed as alopecia areata, illustrating the importance of trichoscopy in correctly identifying this infection even in uncommon sites like the eyebrow.
115 citations
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December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.
November 2025 in “SKIN The Journal of Cutaneous Medicine” This phase 3 trial found that over 50% of adolescents with severe alopecia areata achieved successful hair regrowth after 52 weeks on baricitinib 4-mg, with no new safety concerns reported compared to existing safety profiles.
January 2008 in “HAL (Le Centre pour la Communication Scientifique Directe)” This study identified complex regulatory elements and interactions involving the Hr gene and HR protein that are crucial for hair follicle formation and cycling in mammals.
101 citations
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August 2010 in “PLoS ONE” In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health.
17 citations
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July 2024 in “Frontiers in Oncology” This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.
January 2026 in “PLoS Biology” This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.
2 citations
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September 2023 in “PLoS biology” This study found that mesenchymal cells in mouse and chicken embryonic skin undergo a process of migration driven by tissue tension and WNT secretion, influencing their dispersal and integration into dermal condensates.
35 citations
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May 2021 in “Nature communications” This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.
71 citations
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January 2012 in “PloS one” This study observed that after hair cell loss in the mouse cochlea, supporting cells were replaced by migrating non-specialised cells, with genetic background affecting the rate of tissue re-organization.
25 citations
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May 2013 in “Journal of mammary gland biology and neoplasia” This review examines the roles of Hedgehog and Gli proteins in mouse embryonic mammary development and suggests that Gli3-repressor-mediated off-state of Hedgehog signaling determines mammary fate over hair follicle fate.
4 citations
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January 2009 in “Acta agriculturae Serbica” This study observed that both excessive and deficient selenium levels in a C57BL/6 mouse model were associated with hair loss and changes in hair follicles, likely due to alterations in the hair follicle cycle and increased apoptosis.
3 citations
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December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study revealed key cellular dynamics and interactions during early embryonic mouse skin development, highlighting complex transitions from precursor states to diverse multilayered structures.
1 citations
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July 2023 in “Nature communications” This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.