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In this study, researchers developed vegan exosome-like vesicles from microalgae that mimic mammalian exosomes, demonstrating promising in vitro, ex vivo, and clinical effects such as improved wrinkle depth and elasticity, making them a potential alternative in cosmetic applications.

This study suggests that prenatal genetic diagnosis of MELAS syndrome using amniotic cells may not reliably predict fetal outcomes due to phenotypic diversity observed in siblings with similar levels of mutant mtDNA.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

This review discusses the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles and modern technologies like 3D bioprinting but reports no new clinical results.

This article describes viDA Therapeutics Inc.'s focus on developing new drugs for age-related conditions using their proprietary granzyme-based approach but reports no clinical outcomes, primarily discussing their funding and business strategy.

This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.

This study observed that minoxidil-loaded nanoparticles significantly enhanced skin penetration and hair regrowth in mice within three weeks, without ethanol and propylene glycol, suggesting they are a promising delivery method for treating hair loss.

Minoxidil increases nail growth more than biotin.

Minoxidil works in liver and outer hair root sheath for hair growth.

This study introduced hydrogel microneedles loaded with palladium nanoparticles, which utilize the inherent cytotoxicity of polyethyleneimine to enhance the effectiveness of doxorubicin in treating melanoma, achieving a tumor inhibition rate of up to 98% in a murine model.

This study explored the use of manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and promoting wound healing, finding that these hydrogels effectively ablate melanoma under near-infrared irradiation and enhance vascular endothelial cell activity for tissue regeneration.

In this study, researchers explored how hair follicle neural crest stem cell-derived exosomes, particularly those carrying miR-214-3p, promote neurite outgrowth and aid peripheral nerve regeneration, supported by detailed in vitro and in vivo data on nerve repair and functional recovery in rat models.

This study reports that a new boron/nitrogen-doped carbon nano-onion-based delivery system for doxorubicin enhanced its uptake and anticancer effects in specific cancer cell types, while reducing cardiotoxicity in human heart cells.

This review highlights the potential of microneedle devices in dermatology for conditions like skin aging and autoimmune skin diseases, emphasizing their ability to facilitate targeted drug delivery by creating temporary skin pathways.

This study found that treating mice with naringenin, alone or combined with minoxidil, significantly increased hair growth and follicle diameter and quantity, likely due to its antioxidant and anti-inflammatory properties.

In this study, a needle-free supersonic atomizer delivering Bacopa monnieri extract with hyaluronan was found to enhance hair growth in mice more effectively than the traditional smear method and minoxidil.

This study found that topical treatment with Maneb led to delayed epithelial cell degeneration in hair follicles of rats due to apoptosis.

This review discusses the potential of mesenchymal stromal cell secretome therapies for facial nerve palsy, emphasizing their standardization advantages over cell transplantation, but provides no new clinical results.

This study found that Polygoni multiflori Radix water extracts stimulated hair growth and hair follicle development in mice, suggesting it may be safer than minoxidil.

This article discusses the development and clinical progress of PROTAC technology, particularly focusing on the New Drug Application for vepdegestrant, an estrogen receptor-targeting PROTAC, marking significant advancements in targeted protein degradation therapies.

This review discusses the advances and challenges of using mesenchymal stem cell-derived extracellular vesicles in therapeutic applications and reports no new clinical findings.

This study found that the FER/MLO signaling module plays a crucial role in calcium oscillations and ROS production in root hair tip growth, with the MLO15 protein regulating these processes and restoring disrupted growth and signaling in fer mutant root hairs.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This study developed microneedles combining insulin-like growth factor-1 and type XVII collagen, showing more effective hair regeneration and reduced inflammation compared to minoxidil in a mouse model of androgenetic alopecia.

This study suggests that vellus to terminal hair follicle reconversion can occur in male pattern androgenetic alopecia using an in vivo model with minoxidil and platelet-rich plasma treatment.

This study found that topical minoxidil solution is a safe treatment for androgenetic alopecia, with no increase in cardiovascular events or adverse pregnancy outcomes observed.

This study observed that the active metabolite minoxidil sulfate promotes vascular relaxation by enhancing potassium permeability, which may inform understanding of minoxidil's antihypertensive and hair growth effects.

This case report presents the first Russian patient with Meier-Gorlin syndrome 5, expanding clinical understanding through the identification of two novel CDC6 gene variants.

This study found that topical niosomal minoxidil significantly increased hair count and patient satisfaction compared to conventional minoxidil in men with androgenetic alopecia.

Scale created to measure hair loss in men and women; MK-386 reduces acne; Niaspan treats dyslipidemia; minoxidil increases heart rate.