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    Intravital Two-Photon Imaging of Touch Sensory Axon Morphology in Mouse Skin

    September 2025
    Siu Kai Kong, Emily D. Barnes, Gautham Chelliah, Shan Meltzer
    Studysummary This study presents a two-photon imaging method to visualize low-threshold mechanoreceptor axon terminals in live mouse forepaw skin, enabling repeated high-resolution imaging to study sensory circuits during development and adulthood.
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    Research cited in this study 7

    1. Skin-Type-Dependent Development of Murine Mechanosensory Neurons Developmental Cell · 2023
    2. Three-Dimensional Reconstructions of Mechanosensory End Organs Suggest a Unifying Mechanism Underlying Dynamic, Light Touch bioRxiv (Cold Spring Harbor Laboratory) · 2023
    3. Intravital Imaging of Hair Follicle Regeneration in the Mouse Nature Protocols · 2015
    4. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    5. The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons Cell · 2011
    6. Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice Journal of comparative neurology · 2002
    7. Receptor Types in Cat Hairy Skin Supplied by Myelinated Fibers Journal of neurophysiology · 1968