Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis

The study investigates the remodeling of Merkel cells and their innervating sensory axons in the skin, using live imaging and quantification tools in genetic models. The researchers found significant turnover of Merkel cells and axonal plasticity, which seem to occur independently. The study also established intravital imaging techniques to observe the simultaneous behavior of Merkel cells and their innervation during homeostasis and hair regeneration. However, the study has some limitations, including the dramatic loss of Merkel cells and the potential impact of the depilation agent used. The study also identified a new structure, the Bouton, which mediates interaction between Merkel cells and axons. The researchers concluded that Merkel cells have a stabilizing effect on axon terminals. The study involved the use of transgenic mouse lines and two-photon imaging.