Spatiotemporal Dynamics of Sensory Neuron and Merkel-Cell Remodeling During Epidermal Homeostasis
May 2023
sensory neurons Merkel cells epidermal homeostasis sensory axon terminals epithelial regeneration hair growth axonal remodeling hyperbranched axons kylix endings in vivo imaging two-photon microscopy whole-mount immunohistochemistry skin homeostasis nerve endings hair regeneration axon remodeling imaging techniques
Studysummary This study in adult mice found that somatosensory axons innervating Merkel cells in the skin are highly plastic, with significant remodeling in response to epithelial turnover, and that Merkel cells play a role in limiting axonal branching and promoting their maturation.
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