Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing

The study proposed manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (MCSA hydrogels) for treating melanoma and aiding wound healing. These hydrogels demonstrated controllable gelation, reasonable strength, and excellent bioactivity due to calcium silicate nanowires. Manganese doping enhanced photothermal effects, effectively eradicating melanoma under near-infrared irradiation. Additionally, the combination of manganese and silicon promoted vascular endothelial cell migration, proliferation, and angiogenesis, supporting wound healing. The bifunctional nature of MCSA hydrogels showed promise for melanoma therapy and tissue regeneration.