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Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

Skin cells release substances important for healing and fighting infection, and understanding these could improve skin disorder treatments.

Researchers found genes linked to hair growth cycles in Inner Mongolia cashmere goats, which could help understand and treat hair loss.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

A specific gene mutation causes long hair in Angora rabbits.

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

The skin systems of jawed vertebrates evolved diverse appendages like hair and scales from a common structure over 420 million years ago.

Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.

WNT signaling is crucial for skin development and healing.

Injectable hydrogels are becoming increasingly useful in medicine for drug delivery and tissue repair.

Finasteride-loaded proniosomes effectively promote hair growth in mice.

Hormonal imbalances during menopause may significantly contribute to Frontal Fibrosing Alopecia.

New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

Certain genes related to sulfur metabolism are more active during the growth phase of Cashmere goat wool, and melatonin might help this process.

Low iron and vitamin B12 levels are common in women with chronic hair loss, while low vitamin D is less common.

Mesenchymal stem cells show promise for effective skin repair and regeneration.

People with androgenetic alopecia have different lipid levels in their blood, which vary between men and women, and may be linked to a higher risk of metabolic syndrome.

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

Minoxidil may work for hair loss by reducing androgen sensitivity and altering hormone-related enzymes.

Plant-based compounds can improve wound dressings and skin medication delivery.