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Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Androgenetic alopecia significantly harms quality of life, affecting emotions and relationships.

Low selenium levels can extend lifespan but worsen health issues.

The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.

Tiny vesicles from stem cells could be a new treatment for healing wounds.

The secretome from mesenchymal stem cells shows promise for treating skin conditions and improving skin and hair health, but more research is needed.

MSCs and their exosomes may speed up skin wound healing but need more research for consistent use.

Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.

Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.

Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

HB-EGF boosts the hair growth ability of stem cells, making it a potential hair loss treatment.

The model accurately predicts age from saliva and buccal cells for forensic use.

A specific RNA, circNlgn, contributes to heart damage and scarring caused by the cancer drug doxorubicin.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

COVID-19 can cause various skin issues, like rashes and lesions, which are more common in younger patients and can be linked to more severe complications.

Human hair follicles can be used to create stem cells that might help clone hair for treating hair loss or helping burn patients.

HLA-DRB5 and other genes may be linked to alopecia universalis.

Researchers found WNT10A to be a key gene in developing goat hair follicles.

Researchers created a rat model to study skin damage caused by radiation, which could help develop new treatments.

Sox6 is important in heart and kidney health, affecting diseases like diabetes, heart disease, and high blood pressure.

Mice with extra human KLK14 had hair and skin problems, including weaker cell bonds and inflammation, linked to Netherton syndrome.

Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.

Argan press cake extract might help grow hair and protect hair cells from damage and inflammation.

Acyzol could help treat conditions caused by zinc deficiency.

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

Skin-derived stem cells grow faster and are easier to obtain than hair follicle stem cells, but both can become various cell types.

Current methods can't fully recreate skin and its features, and more research is needed for clinical use.