Nanofat injection is safe and effective for improving skin texture and patient satisfaction.
October 2025 in “Biomolecules” This study found that prolonged intermittent fasting in diet-induced obese mice led to increased levels of inositol monophosphates in white adipose tissue, improved insulin sensitivity, and reduced body weight and fat mass, suggesting a novel metabolic adaptation mechanism.
8 citations
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June 2023 in “Journal of clinical medicine” This study reviews the use of nanofat in facial rejuvenation and cosmetic surgery, highlighting its potential for improving skin appearance and treating conditions like wrinkles and acne scars, yet emphasizes the need for further research into its long-term efficacy and safety.
2 citations
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September 2017 in “Plastic and reconstructive surgery. Global open” This pilot study found that a single session of nanofat treatment may increase hair thickness and density in male patients with androgenic alopecia, with effects lasting up to 12 months in some cases, though results varied.
23 citations
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November 2007 in “Journal of cosmetic dermatology” This study concluded that both phosphatidylcholine alone and with organic silicium effectively reduced submental fat, achieving optimal results after three sessions with mild and temporary adverse effects.
24 citations
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April 2017 in “Aesthetic plastic surgery” In this study, micro-autologous fat transplantation (MAFT) for frontal augmentation using the MAFT-GUN showed high patient satisfaction and no complications among 178 patients, suggesting it may be a reliable method for forehead contouring.
This study found that adding Platelet-Rich Plasma to Nanofat treatment for female pattern hair loss significantly increased terminal hair count and thickness after 6 months.
25 citations
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June 2013 in “Obesity Reviews” This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.
36 citations
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July 2022 in “Stem Cell Research & Therapy” This study concluded that using adipose tissue-derived stromal vascular fraction significantly improved acne scars by increasing collagen content and skin thickness compared to nanofat alone.
2 citations
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January 2013 in “Iraqi journal of Medical Sciences”
1 citations
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September 2018 in “Plastic and reconstructive surgery. Global open” This study found that a single session of nanofat combined with platelet-rich plasma significantly increased hair density and thickness in male androgenic alopecia patients compared to platelet-rich plasma alone, with effects partially persisting at 12 months.
November 2023 in “Journal of cosmetic dermatology” This review article evaluates the effectiveness of autologous fat transplantation in regenerative medicine and rejuvenation, highlighting its biocompatibility and non-immunogenic properties as a facial filler, and notes the variable outcomes based on adipose tissue size.
104 citations
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November 1978 in “JAMA” This article reviews the challenges of fasting and dietary regimens in producing sustained weight loss and reports no new research findings or results.
4 citations
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September 2020 in “Annals of Translational Medicine” This study found that concentrated nanofat, used alone or with decellularized nanofat, may enhance hair growth in mice by activating dermal papilla cells and the anagen phase.
April 2025 in “ALEXMED ePosters” This study found that nanofat injections significantly improved scar characteristics, including collagen deposition, epidermal thickness, and vascularity, due to its anti-inflammatory and immunomodulatory properties.
28 citations
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January 2023 in “Cell Transplantation” This study found that the Hy-Tissue Nanofat product isolates a significant number of proliferative nucleated cells and shows potential for regenerative medicine due to its rich content of adipose-derived stem cells and pluripotent MUSE cells.
June 2023 in “QJM: An International Journal of Medicine” This study found that injecting nanofat into the scalp significantly improved hair density and led to high patient satisfaction among 20 individuals with androgenic alopecia, with minimal side effects, although further research is necessary to refine the technique and confirm these results.
1 citations
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November 2024 in “Journal of Cutaneous and Aesthetic Surgery” This study highlights fat grafting and nanofat as promising options for treating dark circles, offering benefits in improving both volume and skin quality through a single-stage procedure with long-lasting outcomes.
80 citations
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October 1985 in “American Journal of Public Health” This study found significant weight loss and reductions in blood pressure and serum triglycerides among obese patients following a multidisciplinary program with a very low calorie ketogenic diet.
This study found that a protein-sparing modified fast may safely and effectively help maintain weight loss over a short period when supervised by a physician.
January 2023 in “Zenodo (CERN European Organization for Nuclear Research)” This abstract discusses the FitSpresso weight loss supplement's potential benefits and mechanisms but provides no clinical research findings; it reports on its ingredients and consumer ratings instead.
62 citations
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October 2017 in “JAMA facial plastic surgery” This study reported that using condensed nanofat combined with fat grafts significantly improved the aesthetic and functional aspects of atrophic facial scars in 20 patients, as assessed by both patients and plastic surgeons using the Patient and Observer Scar Assessment Scale.
March 2022 in “Al-Azhar International Medical Journal (Print)” In this study, among individuals with androgenic alopecia, stromal vascular fraction injections led to greater clinical improvement and hair density increases compared to nanofat injections, with 26.7% of participants showing great improvement versus 6.7% in the nanofat group after six months.
7 citations
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June 2024 in “Skin Research and Technology” Combining treatments significantly reduces dark circles and wrinkles better than nanofat alone.
1 citations
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January 2024 in “Skin research and technology” This study reviewed various lipolytic agents for reducing submental fat and highlighted that while deoxycholic acid is FDA-approved, other compounds like phosphatidylcholine with deoxycholate lack cosmetic approval due to safety concerns. Understanding these agents' mechanisms and anatomy is crucial for safe fat reduction applications.
October 2023 in “Facial Plastic Surgery” This article describes the PHAT technique for lip and facial rejuvenation but reports no new clinical findings; the technique aims to improve skin quality and enhance surgical outcomes.
1 citations
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January 2023 in “Dermatologic Therapy” This study reported that a single treatment using macrofocused ultrasound energy with a 2 mm transducer significantly reduced pore count, pore volume, and pore index in 34 Thai subjects with enlarged facial pores over a 6-month period, with no adverse events observed.
25 citations
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June 2018 in “Clinical and Experimental Dermatology” This study found that combining fractional radiofrequency microneedling with 5% topical minoxidil improved hair count and thickness more than minoxidil alone in Chinese men with male pattern hair loss.
April 2016 in “Journal of Investigative Dermatology” This study found that a newly developed peptide, FOL-005, significantly inhibited hair growth and counteracted minoxidil's effects in organ-cultured human male scalp skin and mouse models, without apparent toxicity.
August 2019 in “Journal of The American Academy of Dermatology” This study found that a bleach bath treatment with 0.005% HOCI reduced the expression of certain serine proteases in cultured keratinocytes and lowered skin pH in atopic dermatitis patients, potentially improving symptoms by modulating the NF-kB pathway.