Adipose Inositol Monophosphate Metabolism Is Associated With Fasting Regimen-Elicited Metabolic Benefits

    October 2025 in “ Biomolecules ”
    Chunqing Wang, Bilian Liu, Xin Yang, Xi Chen, Shuo Wang, Xing Zhang, Meilian Liu
    Studysummary This study found that prolonged intermittent fasting in diet-induced obese mice led to increased levels of inositol monophosphates in white adipose tissue, improved insulin sensitivity, and reduced body weight and fat mass, suggesting a novel metabolic adaptation mechanism.
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    The study examines the impact of intermittent fasting (IF) on white adipose tissue (WAT) in diet-induced obese mice, focusing on the inositol monophosphate pathway. Over 15 cycles of alternate day fasting (ADF), researchers observed increased levels of inositol monophosphates, specifically myo-inositol-1-phosphate and myo-inositol-3-phosphate, along with upregulation of enzymes ITPK1 and IMPA1. These changes were associated with reductions in body weight and fat mass, improved insulin sensitivity, and enhanced tricarboxylic acid (TCA) cycle activity. The findings suggest that the inositol monophosphate pathway is crucial for fasting-induced metabolic adaptations and may serve as a biomarker for obesity and related metabolic disorders.
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