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A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

A new gene variant causes glucocorticoid resistance in a mother and son.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Blocking glucocorticoid receptors improves glucose metabolism in a PCOS mouse model.

Blocking CRF1 receptors improved male hormone levels and reduced testicular tumor size in men with a specific adrenal condition.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

Drugs targeting the Androgen Receptor are effective for treating prostate cancer and other androgen-related conditions.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Hormonal treatments can improve acne, but they come with potential side effects and risks.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

Adrenal glands delay the start of winter fur growth in mink.

Hormones and genes affect hair growth and male baldness.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Rare adrenal cancers that secrete androgens or estrogens have a poor prognosis and are treated primarily with surgery.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

PCOS is linked to diabetes and insulin resistance, and managing AGEs may help treat related symptoms.

Neurosteroids show promise for treating epilepsy and more research is needed.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.