TLDR With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.
The 2012 document reviewed the management of congenital adrenal hyperplasia (CAH) during pregnancy, highlighting that with improved strategies, women with CAH can have successful pregnancies. It noted that both men and women with CAH have reduced fertility, with women experiencing chronic anovulation and elevated progestin levels, and men facing issues like testicular adrenal rest tumors and oligospermia. The review stressed the importance of suppressing progesterone preconception and individualizing treatment, including glucocorticoid and mineralocorticoid therapies, to achieve healthy pregnancies. It also discussed the need for genetic counseling for CAH patients planning to have children, the use of glucocorticoids every 8 hours to prevent elevated progesterone, and careful management during pregnancy, labor, and delivery, including monitoring for gestational diabetes and considering Caesarean section. Additionally, it touched on the ethical concerns of prenatal dexamethasone treatment to prevent genital virilization in female infants with CAH. The conclusion was that with careful management, patients with CAH can become parents.
30 citations,
June 2012 in “Current Opinion in Endocrinology, Diabetes and Obesity” Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.
100 citations,
May 2011 in “Journal of Pediatric and Adolescent Gynecology” The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.
62 citations,
March 2011 in “European journal of endocrinology” Some parents have a mild form of congenital adrenal hyperplasia without symptoms, and they usually don't need treatment.
88 citations,
April 2017 in “Journal of Pediatric and Adolescent Gynecology” The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.
117 citations,
May 2017 in “Human Reproduction Update” The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.
151 citations,
December 2004 in “Annals of the New York Academy of Sciences” Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.
November 2013 in “John Wiley & Sons, Ltd eBooks” The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.
July 2017 in “Contemporary Endocrinology” The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.
